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Background
Preventive measures to decrease the frequency and intensity of anaphylactic events are essential to provide optimal care for allergic patients. Aggravating factors may trigger or increase the severity of anaphylaxis and therefore need to be recognized and avoided.
Objective
To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.
Methods...
Defective gut immune reactions have been implicated in the development of atopic dermatitis (AD), whereas oral tolerance (OT), that is, the immune unresponsiveness induced by oral antigen administration, protects mice against AD. To investigate this protective role of OT, the transcriptomic profiles of skin were obtained by RNA sequencing from mice that were epicutaneously sensitized, orally tolerized...
BackgroundPrevention guidelines for infants at high risk of allergic disease recommend hydrolysed formula if formula is introduced before 6 months, but evidence is mixed. Adding specific oligosaccharides may improve outcomes.
ObjectiveTo evaluate whether partially hydrolysed whey formula containing oligosaccharides (0.8 g/100 ml) (pHF‐OS) can prevent eczema in high‐risk infants [ISRCTN65195597]....
Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK‐rhinitis (MACVIA‐ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred...
BackgroundPrevious work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.
MethodsWe allocated mothers of food‐allergic children prescribed an AAI for the first time to Anapen...
BackgroundAlthough food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food‐allergic patients. Therefore, the aim of this study was to identify factors which may...
BackgroundOccurrence, elicitors and treatment of severe allergic reactions are recognized and reported differently between countries. We aimed to collect standardized data throughout Europe on anaphylaxis referred for diagnosis and counselling.
MethodsTertiary allergy, dermatology and paediatric units in 10 European countries took part in this pilot phase of the first European Anaphylaxis Registry,...
This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE‐mediated food allergy. Disease‐specific questionnaires are significantly more sensitive than generic ones in measuring the response to interventions or future...
BackgroundEnzyme replacement therapy (ERT) with recombinant human idursulfase is effective for the treatment of Hunter syndrome, mucopolysaccharidosis (MPS) type II. However, various adverse events can occur by the infusion of idursulfase. The purpose was to evaluate the occurrence of infusion‐related allergic reactions, including anaphylaxis, to idursulfase in patients with MPS II receiving ERT and...
To cite this article: Flokstra‐de Blok BMJ, van der Velde JL, Vlieg‐Boerstra BJ, Oude Elberink JNG, DunnGalvin A, Hourihane JO’B, Duiverman EJ, Dubois AEJ. Health‐related quality of life of food allergic patients measured with generic and disease‐specific questionnaires. Allergy 2010; 65: 1031–1038.
AbstractBackground: Health‐related quality of life (HRQL) has never been measured with both generic...
To cite this article: van der Velde JL, Flokstra‐de Blok BMJ, Vlieg‐Boerstra BJ, Oude Elberink JNG, DunnGalvin A, Hourihane JO’B, Duiverman EJ, Dubois AEJ. Development, validity and reliability of the food allergy independent measure (FAIM). Allergy 2010; 65: 630–635.
AbstractBackground: The Food Allergy Quality of Life Questionnaire‐Child Form, ‐Teenager Form and ‐Adult Form (FAQLQ‐CF, ‐TF and...
To cite this article: Flokstra‐de Blok BMJ, Dubois AEJ, Vlieg‐Boerstra BJ, Oude Elberink JNG, Raat H, DunnGalvin A, Hourihane JO’B, Duiverman EJ. Health‐related quality of life of food allergic patients: comparison with the general population and other diseases. Allergy 2010; 65: 238–244.
AbstractBackground: To date no studies have compared generic health‐related quality of life (HRQL) of food allergic...
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