Search results for: Aziz-ur-Rehman

Items from 1 to 20 out of 57 results

article

Synthesis, Kinetics and Computational Explorations of 4‐Phenylpiperazine Bearing N‐(Aryl)‐3‐substituted‐benzamides as Auspicious Tyrosinase Inhibitors

Aurang Zeb, Muhammad Athar Abbasi, Aziz‐ur‐Rehman, Sabahat Zahra Siddiqui, more

Chemistry & Biodiversity > 21 > 4 > n/a - n/a

In the aimed research study, a new series of N‐(aryl)‐3‐[(4‐phenyl‐1‐piperazinyl)methyl]benzamides was synthesized, which was envisaged as tyrosinase inhibitor. The structures of these newly designed molecules were verified by IR, ¹H‐NMR, ¹³C‐NMR, EI‐MS and CHN analysis data. These molecules were screened against tyrosinase and their inhibitory activity explored that these 3‐substituted‐benzamides...

article

A fractional study of mhd casson fluid motion with thermal radiative flux and heat injection/suction mechanism under ramped wall condition: application of rabotnov exponential kernel

Aziz Ur Rehman, Fahd Jarad, Muhammad Bilal Riaz

Acta Mechanica et Automatica > 2024 > Vol. 18, no. 1 > 84--92

The primary objective of this research is to extend the concept of fractionalized Casson fluid flow. In this study, a comprehensive analysis of magnetohydrodynamic (MHD) natural convective flow of Casson fluid is conducted, focusing on obtaining analytical solutions using the non-integer-order derivative known as the Yang–Abdel-Aty–Cattani (YAC) operator. The YAC operator utilized in this research...

article

Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors

Muhammad Athar Abbasi, Hussain Raza, Aziz‐ur‐Rehman, Sabahat Zahra Siddiqui, more

Chemistry & Biodiversity > 20 > 9 > n/a - n/a

In the presented work, a new series of three different 4‐((3,5‐dichloro‐2‐[(2/4‐halobenzyl)oxy]phenyl)sulfonyl)morpholines was synthesized and the structure of these compounds were corroborated by ¹H‐NMR & ¹³C‐NMR studies. The in vitro results established all the three compounds as potent tyrosinase inhibitors relative to the standard. The Kinetics mechanism plots established that compound 8 inhibited...

article

The prevalence of low health literacy in undergraduate students in Pakistan

Aziz‐ur Rehman, Salman Bin Naeem, Anthony Faiola

Health Information & Libraries Journal > 40 > 1 > 103 - 108

This Regular Feature is based on a PhD study assessing the level of health literacy among university students in Pakistan. A cross‐sectional survey was carried out using the validated European Health Literacy Survey (HLS‐EU‐Q) and non‐parametric tests used to analyse data with the aim of determining the influence of personal determinants on health literacy skills. The findings of the study concluded...

article

2‐Aminothiazole‐Oxadiazole Bearing N‐Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure‐Activity Relationship, and Binding Conformations

Hussain Raza, Abdul Rehman Sadiq Butt, Muhammad Athar Abbasi, Aziz‐ur‐Rehman, more

Chemistry & Biodiversity > 20 > 2 > n/a - n/a

A multi‐step synthesis of novel bi‐heterocyclic N‐arylated butanamides was consummated through a convergent strategy and the structures of these medicinal scaffolds, 7a–h, were corroborated using spectral techniques. The in vitro analysis of these hybrid molecules revealed their potent tyrosinase inhibition as compared to the standard used. The kinetics mechanism was investigated through Lineweaver‐Burk...

article

Epidemiological and hematological investigation of dengue virus infection

Faheem Anwar, Sami Ullah, Aziz ur Rehman Aziz, Abid Ur Rehman, more

Microbiology and Immunology > 66 > 9 > 426 - 432

Dengue is a mosquito‐borne viral illness that infects humans. For the past few decades, it has been declared a global public health problem. The current study, conducted at the district headquarter hospital (DHQ) Bannu between June to September 2018, was based on the seroprevalence of antibodies against dengue virus serotypes and their hematological parameters among the patients. A total of 1738 individuals...

article

Optimal existence of fractional order computer virus epidemic model and numerical simulations

Ali Akgül, Muhammad Sajid Iqbal, Umbreen Fatima, Nauman Ahmed, more

Mathematical Methods in the Applied Sciences > 44 > 13 > 10673 - 10685

Aim of this article is to analyze the fractional order computer epidemic model. To this end, a classical computer epidemic model is extended to the fractional order model by using the Atangana–Baleanu fractional differential operator in Caputo sense. The regularity condition for the solution to the considered system is described. Existence of the solution in the Banach space is investigated and some...

article

Convergent synthesis of carbonic anhydrase inhibiting bi‐heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies

Farhan M. Khan, Muhammad A. Abbasi, Aziz‐ur‐Rehman, Sabahat Z. Siddiqui, more

Journal of Heterocyclic Chemistry > 58 > 5 > 1089 - 1103

By using a convergent methodology, a novel series of N‐arylated 4‐yl‐benzamides containing a bi‐heterocyclic thiazole–triazole core was synthesized, and the structures of these hybrid molecules, 9a–k, were corroborated through spectral analyses. The in vitro studies of these multifunctional molecules demonstrated their potent carbonic anhydrase inhibition relative to the standard used. The kinetics...

article

Design and analysis of a discrete method for a time‐delayed reaction–diffusion epidemic model

Jorge E. Macías‐Díaz, Nauman Ahmed, Muhammad Jawaz, Muhammad Rafiq, more

Mathematical Methods in the Applied Sciences > 44 > 6 > 5110 - 5122

In this work, we propose a time‐delayed reaction–diffusion model to describe the propagation of infectious viral diseases like COVID‐19. The model is a two‐dimensional system of partial differential equations that describes the interactions between disjoint groups of a human population. More precisely, we assume that the population is conformed by individuals who are susceptible to the virus, subjects...

article

Comparative conventional and microwave assisted synthesis of heterocyclic oxadiazole analogues having enzymatic inhibition potential

Jamila Javid, Aziz‐ur‐Rehman, Muhammad A. Abbasi, Sabahat Z. Siddiqui, more

Journal of Heterocyclic Chemistry > 58 > 1 > 93 - 110

A comparative microwave assisted and conventional synthetic strategies were applied to synthesize heterocyclic 1,3,4‐oxadiazole analogues as active anti‐enzymatic agents. Green synthesis of compound 1 was achieved by stirring 4‐methoxybenzenesulfonyl chloride (a) and ethyl piperidine‐4‐carboxylate (b). Compound 1 was converted into respective hydrazide (2) by hydrazine and then into 1,3,4‐oxadiazole...

article

Bladder cancer hunting: A microfluidic paper‐based analytical device

Qingyun Jiang, Tingting Han, Haijun Ren, Aziz Ur Rehman Aziz, more

ELECTROPHORESIS > 41 > 16-17 > 1509 - 1516

Bladder cancer is the fourth most common cancer in men, and it is becoming a prevalent malignancy. Most of the regular clinical examinations are prompt evaluations with cystoscopy, renal function testing, which require high‐precision instrument, well‐trained operators, and high cost. In this study, a microfluidic paper‐based analytical device (μPAD) was fabricated to detect nuclear matrix protein...

article

Differential phosphorylation regulates the shear stress‐induced polar activity of Rho‐specific guanine nucleotide dissociation inhibitor α

Fei Xie, Shuai Shao, Baohong Zhang, Sha Deng, more

Journal of Cellular Physiology > 235 > 10 > 6978 - 6989

The activity of Rho‐specific guanine nucleotide dissociation inhibitor α (RhoGDIα) is regulated by its own phosphorylation at different amino acid sites. These phosphorylation sites may have a crucial role in local Rho GTPases activation during cell migration. This paper is designed to explore the influence of phosphorylation on shear stress‐induced spatial RhoGDIα activation. Based on the fluorescence...

article

Convergent synthesis, free radical scavenging, Lineweaver‐Burk plot exploration, hemolysis and in silico study of novel indole‐phenyltriazole hybrid bearing acetamides as potent urease inhibitors

Wajiha Khan, Muhammad A. Abbasi, Aziz‐ur Rehman, Sabahat Z. Siddiqui, more

Journal of Heterocyclic Chemistry > 57 > 7 > 2955 - 2968

In the current paper, through a convergent multi‐step approach, a library of novel indole‐phenyltriazole hybrids containing an amide moiety (9a‐k) was synthesized. The structural verification of all synthesized molecules was accomplished by CHN and spectral analyses data. These synthesized bi‐heterocyclic derivatives (9a‐k) were evaluated for their anti‐ulcer potential by inhibitory action against...

article

Microwave‐assisted synthesis of triazole derivatives conjugated with piperidine as new anti‐enzymatic agents

Naeem A. Virk, Aziz‐ur‐ Rehman, Muhammad A. Abbasi, Sabahat Z. Siddiqui, more

Journal of Heterocyclic Chemistry > 57 > 3 > 1387 - 1402

The current study was aimed for the study of piperidine‐based triazole compounds for their biological potential against various enzymes. A novel library of compounds, 9a‐r, having piperidine, 1,2,4‐triazole, and propanamides was synthesized through consecutive steps including the formation of sulfonamide, hydrazide, 1,2,4‐triazole, and thio‐ether. Initially, 4‐methoxybenzenesulfonyl chloride (1) and...

article

A novel five‐step synthetic route to 1,3,4‐oxadiazole derivatives with potent α‐glucosidase inhibitory potential and their in silico studies

Muhammad Iftikhar, Shahnawaz, Muhammad Saleem, Naheed Riaz, more

Archiv der Pharmazie > 352 > 12 > n/a - n/a

A series of new N‐aryl/aralkyl derivatives of 2‐methyl‐2‐{5‐(4‐chlorophenyl)‐1,3,4‐oxadiazole‐2ylthiol}acetamide were synthesized by successive conversions of 4‐chlorobenzoic acid (a) into ethyl 4‐chlorobenzoate (1), 4‐chlorobenzoylhydrazide (2) and 5‐(4‐chlorophenyl)‐1,3,4‐oxadiazole‐2‐thiol (3), respectively. The required array of compounds (6a–n) was obtained by the reaction of 1,3,4‐oxadiazole...

article

Bi‐heterocyclic benzamides as alkaline phosphatase inhibitors: Mechanistic comprehensions through kinetics and computational approaches

Muhammad A. Abbasi, Majid Nazir, Aziz ur‐Rehman, Sabahat Z. Siddiqui, more

Archiv der Pharmazie > 352 > 3 > n/a - n/a

Novel bi‐heterocyclic benzamides were synthesized by sequentially converting 4‐(1H‐indol‐3‐yl)butanoic acid (1) into ethyl 4‐(1H‐indol‐3‐yl)butanoate (2), 4‐(1H‐indol‐3‐yl)butanohydrazide (3), and a nucleophilic 5‐[3‐(1H‐indol‐3‐yl)propyl]‐1,3,4‐oxadiazole‐2‐thiol (4). In a parallel series of reactions, various electrophiles were synthesized by reacting substituted anilines (5a–k) with 4‐(chloromethyl)benzoylchloride...

article

N-(5-Methyl-1,3-Thiazol-2-yl)-2-{[5-((Un)Substituted- Phenyl)1,3,4-Oxadiazol-2-yl]Sulfanyl}acetamides. Unique Biheterocycles as Promising Therapeutic Agents

M. A. Abbasi, M. S. Ramzan, Aziz-ur-Rehman, S. Z. Siddiqui, more

Russian Journal of Bioorganic Chemistry > 2018 > 44 > 6 > 801-811

An electrophile, 2-bromo-N-(5-methyl-1,3-thiazol-2-yl)acetamide, was synthesized by the reaction of 5-methyl-1,3-thiazol-2-amine and bromoacetyl bromide in an aqueous medium. In a parallel scheme, a series of (un)substituted benzoic acids was converted sequentially into respective esters, acid hydrazides, and then into 1,3,4-oxadiazole heterocyclic cores. The electrophile was coupled with the aforementioned...

article

Synthesis, in vitro and in silico studies of novel potent urease inhibitors: N-[4-({5-[(3-Un/substituted-anilino-3-oxopropyl)sulfanyl]-1,3,4-oxadiazol-2-yl}methyl)-1,3-thiazol-2-yl]benzamides

Muhammad Athar Abbasi, Mubashir Hassan, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, more

Bioorganic & Medicinal Chemistry > 2018 > 26 > 13 > 3791-3804

The present article describes the synthesis, in vitro urease inhibition and in silico molecular docking studies of a novel series of bi-heterocyclic bi-amides. The synthesis of title compounds was initiated by benzoylation, with benzoyl chloride (1), of the key starter ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (2) in weak basic aqueous medium followed by hydrazide formation, 4, and cyclization with...

article

Method Development and Stress Degradation Profile of 5-Benzyl-1,3,4-Oxadiazole-2-Thiol Studied by UV Spectroscopy

Shaista Qamar, Khalid Hussain, Nadeem Irfan Bukhari, Naureen Shehzadi, more

Pharmaceutical Chemistry Journal > 2018 > 52 > 3 > 278-283

Considering the pharmacological activities of 5-benzyl-1,3,4-oxadiazole-2-thiol (OXPA), the present study aimed to develop and validate a UV-spectroscopic method according to the ICH guidelines to be used to study degradation profile of the compound. The method was developed at 263 nm, the wavelength giving maximum absorbance. Linearity of the method was evaluated by analyzing a series of standard...

article

The impact of Yb and Co on structural, magnetic, electrical and photocatalytic behavior of nanocrystalline multiferroic BiFeO3 particles

Sajjad Ahmad, Muhammad Azhar Khan, Mansoor Sarfraz, Aziz ur Rehman, more

Ceramics International > 2017 > 43 > 18 > 16880- 16887

The nanocrystalline particles of BiFO₃,co-doped with ytterbium and cobalt Bi_1−xYb_xCo_yFe_1−yO₃ (BYCFO) were fabricated via micro-emulsion method using cetyltrimethyl ammonium bromide (CTAB) as a surfactant. The dopant contents were kept x = 0.00, 0.025, 0.05, 0.075, 0.1, 0.125 and y = 0.00, 0.05, 0.1, 0.15, 0.2, 0.25 for six different compositions. The BYCFO-nanoparticles were investigated for structure,...

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INFONA - science communication portal

Search results for: Aziz-ur-Rehman

Synthesis, Kinetics and Computational Explorations of 4‐Phenylpiperazine Bearing N‐(Aryl)‐3‐substituted‐benzamides as Auspicious Tyrosinase Inhibitors

A fractional study of mhd casson fluid motion with thermal radiative flux and heat injection/suction mechanism under ramped wall condition: application of rabotnov exponential kernel

Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors

The prevalence of low health literacy in undergraduate students in Pakistan

2‐Aminothiazole‐Oxadiazole Bearing N‐Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure‐Activity Relationship, and Binding Conformations

Epidemiological and hematological investigation of dengue virus infection

Optimal existence of fractional order computer virus epidemic model and numerical simulations

Convergent synthesis of carbonic anhydrase inhibiting bi‐heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies

Design and analysis of a discrete method for a time‐delayed reaction–diffusion epidemic model

Comparative conventional and microwave assisted synthesis of heterocyclic oxadiazole analogues having enzymatic inhibition potential

Bladder cancer hunting: A microfluidic paper‐based analytical device

Differential phosphorylation regulates the shear stress‐induced polar activity of Rho‐specific guanine nucleotide dissociation inhibitor α

Convergent synthesis, free radical scavenging, Lineweaver‐Burk plot exploration, hemolysis and in silico study of novel indole‐phenyltriazole hybrid bearing acetamides as potent urease inhibitors

Microwave‐assisted synthesis of triazole derivatives conjugated with piperidine as new anti‐enzymatic agents

A novel five‐step synthetic route to 1,3,4‐oxadiazole derivatives with potent α‐glucosidase inhibitory potential and their in silico studies

Bi‐heterocyclic benzamides as alkaline phosphatase inhibitors: Mechanistic comprehensions through kinetics and computational approaches

N-(5-Methyl-1,3-Thiazol-2-yl)-2-{[5-((Un)Substituted- Phenyl)1,3,4-Oxadiazol-2-yl]Sulfanyl}acetamides. Unique Biheterocycles as Promising Therapeutic Agents

Synthesis, in vitro and in silico studies of novel potent urease inhibitors: N-[4-({5-[(3-Un/substituted-anilino-3-oxopropyl)sulfanyl]-1,3,4-oxadiazol-2-yl}methyl)-1,3-thiazol-2-yl]benzamides

Method Development and Stress Degradation Profile of 5-Benzyl-1,3,4-Oxadiazole-2-Thiol Studied by UV Spectroscopy

The impact of Yb and Co on structural, magnetic, electrical and photocatalytic behavior of nanocrystalline multiferroic BiFeO3 particles

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