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IntroductionOpioid‐induced constipation (OIC) is common in people treated with opioids and poses risks for physical sequelae, analgesic discontinuation, and decreased quality of life.
MethodsTargeted literature review of evidence‐ and consensus‐based data on appropriate diagnosis, concise definition, and conventional and newer management strategies for OIC.
ResultsOIC may develop early and need...
Physical dependence or withdrawal is an expected effect of prolonged opioid therapy. Oxytrex (oxycodone + ultralow-dose naltrexone) is an investigational drug shown here to minimize physical dependence while providing strong analgesia with twice-daily dosing. In this 719-patient, double-blind, placebo- and active-controlled Phase III clinical trial in chronic low back pain, patients were randomized...
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