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Supramolecular polymers (SPs) have attracted broad interest because of their intriguing features and functions. Host–guest interactions often impart tunable physicochemical properties, reversible hierarchical organization, and stimuli‐responsiveness to SPs for diverse biomedical applications. Characterized by strong but dynamic interactions with guest molecules, cucurbit[n]uril (CB[n]) has shown great...
Supramolecular polymers (SPs) have attracted broad interest because of their intriguing features and functions. Host–guest interactions often impart tunable physicochemical properties, reversible hierarchical organization, and stimuli‐responsiveness to SPs for diverse biomedical applications. Characterized by strong but dynamic interactions with guest molecules, cucurbit[n]uril (CB[n]) has shown great...
Improving the precise accumulation and retention of nanomedicines in tumor cells is one of the keys to effective therapy of tumors. Herein, supramolecular peptides capped Au nanocages (AuNCs) that may self‐aggregate into micron‐sized clusters intracellularly in response to spermine (SPM), leading to specific accumulation and retention of AuNCs in SPM‐overexpressed tumor cells, are developed. In this...
Breast Cancer Therapy
In article number 2201971, Ruibing Wang and co‐workers develop supramolecular peptide (based upon the host–guest interaction between cucurbit[7]uril and Phe‐Phe‐Val‐Leu‐Lys) capped Au nanocages, to allow self‐aggregation into micron‐sized clusters inside spermine‐overexpressed tumor cells, leading to specific accumulation and retention of Au nanocages in breast tumor for synergistic...
The precise accumulation and extended retention of nanomedicines in the tumor tissue has been highly desired for cancer therapy. Here a novel supramolecular‐peptide derived nanodrug (SPN) that can be transformed to microfibers in response to intracellular polyamine in cancer cells for significantly enhanced tumor specific accumulation and retention is developed. The supramolecular‐peptide is constructed...
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