Search results for: David M Irwin

Items from 1 to 20 out of 61 results

article

Genomic evolution of island birds from the view of the Swinhoe's pheasant (Lophura swinhoii)

Xiao Xu, Chen Wang, Chunzhong Xu, Jiaqing Yuan, more

Molecular Ecology Resources > 24 > 2 > n/a - n/a

Island endemic birds account for the majority of extinct vertebrates in the past few centuries. To date, the evolutionary characteristics of island endemic bird's is poorly known. In this research, we de novo assembled a high‐quality chromosome‐level reference genome for the Swinhoe's pheasant, which is a typical endemic island bird. Results of collinearity tests suggest rapid ancient chromosome rearrangement...

article

Embryonic and skeletal development of the albino African clawed frog (Xenopus laevis)

Zhixin Shan, Shanshan Li, Chenghua Yu, Shibin Bai, more

Journal of Anatomy > 242 > 6 > 1051 - 1066

The normal stages of embryonic development for wild‐type Xenopus laevis were established by Nieuwkoop and Faber in 1956, a milestone in the history of understanding embryonic development. However, this work lacked photographic images and staining for skeleton structures from the corresponding stages. Here, we provide high‐quality images of embryonic morphology and skeleton development to facilitate...

article

Comparison of embryonic development, from HH21 to HH40, between ostrich (Struthio camelus) and chicken (Gallus gallus)

Shibin Bai, Shanshan Li, Xiaoping Li, Shiyu Zhu, more

Developmental Dynamics > 252 > 5 > 668 - 681

Background The chicken has been a representative model organism to study embryonic development in birds, however important differences exist among this class of species. As a representative of one of oldest existing clades of birds, the African ostrich (Struthio camelus), has the largest body among birds, and has two toes. Our purpose is to establish the corresponding stages in ostrich embryo development...

article

A new canine distemper virus lineage identified from red pandas in China

Ruichen Wang, Xiaohu Wang, Junqiong Zhai, Pian Zhang, more

Transboundary and Emerging Diseases > 69 > 4 > e944 - e952

Canine distemper virus (CDV) is a highly contagious virus that causes multi‐systemic, sub‐clinical to fatal diseases in a wide range of carnivore species. Based on the sequences of the haemagglutinin (H) gene, CDV strains have been classified into 18 major genetic lineages. In this study, we characterized the genomes of CDV isolated from the lungs of two dead red pandas in China. Histopathological...

article

A missense mutation in ASIP is associated with light point variation in donkeys

Yan Yu, Songyang Shang, Xiaoying Zhang, Zhe Wang, more

Animal Genetics > 51 > 4 > 629 - 629

article

547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates

Ming-Li Li, Shi-Hao Wu, Jin-Jin Zhang, Hang-Yu Tian, more

Genome Biology > 2019 > 20 > 1 > 1-17

Background Brain aging is a complex process that depends on the precise regulation of multiple brain regions; however, the underlying molecular mechanisms behind this process remain to be clarified in non-human primates. Results Here, we explore non-human primate brain aging using 547 transcriptomes originating from 44 brain areas in rhesus macaques (Macaca mulatta). We show that expression connectivity...

article

Stromal vascular fraction promotes migration of fibroblasts and angiogenesis through regulation of extracellular matrix in the skin wound healing process

Hongsen Bi, Hui Li, Chen Zhang, Yiqing Mao, more

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-21

Background A refractory wound is a typical complication of diabetes and is a common outcome after surgery. Current approaches have difficulty in improving wound healing. Recently, non-expanded stromal vascular fraction (SVF), which is derived from mature fat, has opened up new directions for the treatment of refractory wound healing. The aim of the current study is to systematically investigate the...

article

Adaptive Evolution of C-Type Lysozyme in Vampire Bats

Chunzheng He, Yujia Wei, Yubo Zhu, Yu Xia, more

Journal of Molecular Evolution > 2019 > 87 > 9-10 > 309-316

In mammals, chicken-type (c-type) lysozymes are part of the innate immune system, killing bacteria by degrading peptidoglycan in their cell walls. Many of the studies on the evolution of c-type lysozymes have focused on its new digestive function, including the duplicated stomach lysozymes in ruminants. Similarly, in bats, gene duplications and subsequent adaptive evolution of c-type lysozyme have...

article

Construction of a sensitive pyrogen‐testing cell model by site‐specific knock‐in of multiple genes

Ruobi Hu, Hui Li, Zhen Lei, Qing Han, more

Biotechnology and Bioengineering > 116 > 10 > 2652 - 2661

A pyrogen test is crucial for evaluating the safety of drugs and medical equipment, especially those involved in injections. As existing pyrogen tests, including the rabbit pyrogen test, the limulus amoebocyte lysate (LAL) test and the monocyte activation test have limitations, development of new models for pyrogen testing is necessary. Here we develop a sensitive cell model for pyrogen test based...

article

Application of a TLR overexpression cell model in pyrogen detection

Qing Han, Ruobi Hu, Hui Li, Zhen Lei, more

Biotechnology and Bioengineering > 116 > 6 > 1269 - 1279

Pyrogens are components derived from microorganisms that induce complex inflammatory responses. Current approaches to detect pyrogens are complex and difficult to replicate, thus there is a need for new methods to detect pyrogens. We successfully constructed a pyrogen‐sensitive cell model by overexpressing Toll‐like receptor (TLR)2, TLR4, MD2, and CD14 in HEK293 cells. Since the cytokine IL‐6 is specifically...

article

Whole genomes and transcriptomes reveal adaptation and domestication of pistachio

Lin Zeng, Xiao-Long Tu, He Dai, Feng-Ming Han, more

Genome Biology > 2019 > 20 > 1 > 1-13

Background Pistachio (Pistacia vera), one of the most important commercial nut crops worldwide, is highly adaptable to abiotic stresses and is tolerant to drought and salt stresses. Results Here, we provide a draft de novo genome of pistachio as well as large-scale genome resequencing. Comparative genomic analyses reveal stress adaptation of pistachio is likely attributable to the expanded cytochrome...

article

Evolutionary dynamics of avian influenza A H7N9 virus across five waves in mainland China, 2013–2017

Dan Xiang, Zhiqing Pu, Tingting Luo, Fucheng Guo, more

Journal of Infection > 2018 > 77 > 3 > 205-211

Since its emergence in March 2013, novel avian influenza A H7N9 virus has triggered five epidemics of human infections in China. This raises concerns about the pandemic threat of this quickly evolving H7N9 subtype for humans. In this study, we evaluated all available genomes for H7N9 and H9N2 influenza A viruses. Our assessment discovered that H7N9 of the 1st wave had the lowest nucleotide diversity,...

article

The H7N9 viruses have lost most of their previous lineages in the fifth wave

Dan Xiang, David M. Irwin, Yongyi Shen

Journal of Infection > 2018 > 76 > 4 > 417-418

article

Evolution of the vertebrate insulin receptor substrate (Irs) gene family

Ahmad Al-Salam, David M. Irwin

BMC Evolutionary Biology > 2017 > 17 > 1 > 1-14

Background Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3, has been pseudogenized in humans. While it is known that the Irs gene family originated in vertebrates, it is not known...

article

The origin of chow chows in the light of the East Asian breeds

Hechuan Yang, Guodong Wang, Meng Wang, Yaping Ma, more

BMC Genomics > 2017 > 18 > 1 > 1-13

Background East Asian dog breeds are one of the most ancient groups of dogs that radiated after the domestication of the dog and represent the most basal lineages of dog evolution. Among these, the Chow Chow is an ancient breed that embodies very distinct morphological and physiological features, such as sturdy build, dense coat, and blue/purple tongue. Results Using a Restricted site Associated...

article

Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy

Hui Li, Yiqing Mao, Qun Zhang, Qing Han, more

Journal of Ethnopharmacology > 2016 > 192 > C > 459-470

Using insects, such as the cockroach, for the treatment of disease has a long history in traditional Chinese medicine. Xinmailong (XML) Injection, a bioactive composite extracted from Periplaneta americana (a species of cockroach), shows reasonable protective effects against cardiovascular injury and was approved for the use in the treatment of cardiac dysfunction in 2006, yet its cardio protective...

article

Prolonged treatment with 3-isobutyl-1-methylxanthine improves the efficiency of differentiating 3T3-L1 cells into adipocytes

Yongjie Hua, Shanshan Ke, Yao Wang, David M. Irwin, more

Analytical Biochemistry > 2016 > 507 > C > 18-20

Until now, the low efficiency of current protocols or kits for the differentiation of 3T3-L1 preadipocytes makes it difficult to continue the studies of the cellular and molecular mechanisms in adipocytes. Here we present a productive and highly efficient protocol for the differentiation of 3T3-L1 cells that uses a prolonged treatment with 3-isobutyl-1-methylxanthine (IBMX) during the differentiated...

article

Repetitive transpositions of mitochondrial DNA sequences to the nucleus during the radiation of horseshoe bats (Rhinolophus, Chiroptera)

Huizhen Shi, Ji Dong, David M. Irwin, Shuyi Zhang, more

Gene > 2016 > 581 > 2 > 161-169

Transposition of mitochondrial DNA into the nucleus, which gives rise to nuclear mitochondrial DNAs (NUMTs), has been well documented in eukaryotes. However, very few studies have assessed the frequency of these transpositions during the evolutionary history of a specific taxonomic group. Here we used the horseshoe bats (Rhinolophus) as a case study to determine the frequency and relative timing of...

chapter

Ultrasound-Guided Lumbar Zygapophysial (Facet) Nerve Block

David M. Irwin, Michael Gofeld

Atlas of Ultrasound-Guided Procedures in Interventional Pain Management > Spine Sonoanatomy and Ultrasound-Guided Spine Injections > 149-156

The concept of blocking spinal nerves is validated by relieving the pain transmitted by that nerve. Similarly, blocking a painful structure (e.g., inflamed joint) should provide at least temporal alleviation of pain. Diagnostic and therapeutic lumbar zygapophysial (facet) nerve and joint interventions are among the most commonly performed injections in pain management. Traditionally, fluoroscopic...

article

Diversification of Sisorid catfishes (Teleostei: Siluriformes) in relation to the orogeny of the Himalayan Plateau

Chuanjiang Zhou, Xuzhen Wang, Xiaoni Gan, Yaping Zhang, more

Chinese Science Bulletin > 2016 > 61 > 13 > 991-1002

Sisorid catfishes are primarily limited in distribution to rivers of the Himalayan region and Tibetan Plateau. These species have external morphologies that are adapted for extremely fast-flowing riverine systems. Given the diversity of the group and the above qualities of these catfishes, this lineage serves as an ideal group for inferring the geological history of this region based on their phylogenetic...

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INFONA - science communication portal

Search results for: David M Irwin

Genomic evolution of island birds from the view of the Swinhoe's pheasant (Lophura swinhoii)

Embryonic and skeletal development of the albino African clawed frog (Xenopus laevis)

Comparison of embryonic development, from HH21 to HH40, between ostrich (Struthio camelus) and chicken (Gallus gallus)

A new canine distemper virus lineage identified from red pandas in China

A missense mutation in ASIP is associated with light point variation in donkeys

547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates

Stromal vascular fraction promotes migration of fibroblasts and angiogenesis through regulation of extracellular matrix in the skin wound healing process

Adaptive Evolution of C-Type Lysozyme in Vampire Bats

Construction of a sensitive pyrogen‐testing cell model by site‐specific knock‐in of multiple genes

Application of a TLR overexpression cell model in pyrogen detection

Whole genomes and transcriptomes reveal adaptation and domestication of pistachio

Evolutionary dynamics of avian influenza A H7N9 virus across five waves in mainland China, 2013–2017

The H7N9 viruses have lost most of their previous lineages in the fifth wave

Evolution of the vertebrate insulin receptor substrate (Irs) gene family

The origin of chow chows in the light of the East Asian breeds

Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy

Prolonged treatment with 3-isobutyl-1-methylxanthine improves the efficiency of differentiating 3T3-L1 cells into adipocytes

Repetitive transpositions of mitochondrial DNA sequences to the nucleus during the radiation of horseshoe bats (Rhinolophus, Chiroptera)

Ultrasound-Guided Lumbar Zygapophysial (Facet) Nerve Block

Diversification of Sisorid catfishes (Teleostei: Siluriformes) in relation to the orogeny of the Himalayan Plateau

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