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Decorin was reported to bind transforming growth factor-beta (TGF-β 1 ) and neutralise some of its activity as a key regulator of wound contraction and hypertrophic scar formation. In this study, we investigated whether recombinant human decorin affected TGF-β 1 -induced fibroblast contractile activity, by using fibroblast-populated collagen lattice with decorin added to the collagen...
Hypertrophic scarring remains a major problem for patients who have suffered deep burns. The pathophysiology underlying hypertrophic scar formation may be driven by the biological activity of transforming growth factor beta1 (TGF-β 1 ). Decorin is a human proteoglycan that inactivates the effect of TGF-β 1 and therefore displays a beneficial effect of antifibrosis in various tissues...
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