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Objective
This study tested the hypothesis that treatment with the glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from the loss of lean and fat mass (metabolic adaptation).
Methods
This Phase 1b, double‐blind, randomized, placebo‐controlled study was conducted at two centers in inpatient...
Objective
This analysis aimed to measure the intraparticipant reliability—the intraclass correlation coefficient—of all the components of daily energy expenditure (EE) (24‐hour EE, sleep EE, resting EE, basal EE, and thermic effect of food) over a period of 3 consecutive days in 35 study participants.
Methods
The components of daily EE and substrate use (respiratory exchange ratio) were measured...
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