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Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over 20 years ago, is a simplistic approach of the links between upper‐ and lower‐airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic...
The immunologic profile of 18 CDA (25-66 years) divided at random into two groups treated with LDMTX (oral dose 15mg per week) or placebo for the period of 12 weeks was investigated. Four weeks before the start of therapy and on week 4, 8, and 12 after, the parameters of natural and specific immunity in peripheral blood were assessed.No changes were found between immunology parameters within each...
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