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An “off-on” phosphorescent aptasensor based on the 3-mercaptopropionic acid (MPA) capped Mn-doped ZnS quantum dots (MPA-Mn:ZnS QDs)/aptamer hybrid system was developed to detect adenosine triphosphate (ATP) in biological fluids. The phosphorescence of MPA-Mn:ZnS QDs was obviously quenched when ATP aptamer was added due to the aggregation induced effect. ATP aptamer, adsorbed on the surface of the...
In this paper, a very simple, easily-operated and universal platform is proposed for tumor marker detection. In this strategy, tumor marker-specific aptamer, which can quench the fluorescence of polyfluorene-based cationic conjugated polyelectrolytes (PFN+), are used as recognizing probes. Upon addition of tumor marker, the aptamer can be assembled into the tumor marker-aptamer complex, resulting...
This paper describes the poly(divinylbenzene) (PDVB) supported synthesis of quaternized hyperbranched macromolecules (QHMs) and its use as a highly selective, high-capacity mixed-mode anion-exchange (MAX) sorbent. In detail, the aminated PDVB support was firstly synthesized by copolymerization of divinylbenzene and 2-(diethylamino)ethyl methacrylate via Pickering emulsion polymerization. The QHMs...
A novel nanoporous carbon (NPC) was constructed by utilizing the porous aromatic framework-6 (PAF-6) as both the template and carbon source along with KOH as a chemical activator. The newly-synthesized PAF-6 derived nanoporous carbon (PAF-6-NPC) was then employed as a solid-phase microextraction (SPME) fiber coating. Coupled with gas chromatography-flame ionization detection, the PAF-6-NPC fiber-based...
In this study, 3-ethyl-2-methylbenzothiazolium iodide and nitrophenyl-2-furancarboxaldehyde were used to synthesize a new fluorescent and chromogenic dual channel signal cyanide ion probe M, which showed high selectivity towards CN- analysis and strong antijamming capability towards other anions. When CN- is present in the solution, probe M indicates an obvious blue shift in UV–vis absorbance spectra,...
Using photoelectrochemical (PEC) platform for ultrasensitive detection of sulfate-reducing bacteria (SRB) is a big challenge since sensor sensitive component can be damaged by corrosive metabolites. In this work, a novel bio-etching strategy for sensitizing PEC platform is developed to detect SRB. In the presence of bacterial metabolite (H2S), BiOCl platform can be bio-etched to form Bi2S3/BiOCl p-n...
The isolation and depletion of highly-abundant proteins and peptides is of vital importance for the screening and monitoring of biomarkers which are low stoichiometry in proteomics and protein-based biotechnologies. Here we have designed and synthesized a series of magnetic microspheres MnFe2O4 @SiO2 @ Lanthanide Oxides (La= Ce, Sm, Er, Tm, Yb) whose surface were functionalized by lanthanide oxides...
Superhydrophobic substrate is applied in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) detection due to its confinement effect. The weak interaction of superhydrophobic surface with water/salts makes it potential in one-step enrichment and desalting of peptide in MALDI MS analysis. We fabricate a superhydrophobic substrate by spin-coating poly(dimethyl siloxane) (PDMS) on...
A newly fluorescence probe for detection of Serotonin based on a Mn-doped ZnS quantum dots@silica nanoparticle@molecularly imprinted polymers (QDs@SiO2@MIPs) was successfully created. QDs@SiO2@MIPs were characterized by scanning electron microscope, transmission electron microscope, Fourier transform infrared spectroscopy, UV spectroscopy, X-ray powder diffraction, and fluorescence spectroscopy. A...
Owing to the advantages of transient, broadband, low-energy, transmission and high frequency accuracy, terahertz frequency domain spectroscopy (THz-FDS) has been introduced and pioneered for determining chlortetracycline hydrochloride (CCH) and tetracycline hydrochloride (TCH) in environmental samples, such as chicken, rice and soils. Their THz fingerprint spectra were located in the range of 0.4–1...
Multiple miRNA detection is often limited by sample, time-consuming, and complicated procedures. To address such challenges, we present a relatively simple and amplification-free fluorescent strategy based on hybridization-initiated exonuclease resistance for simultaneous detection of multiple miRNAs in a single tube. Single-stranded linear DNA probes were designed with dual roles of capture and reporter...
In this work, we analyzed the performance of the Electro-Filtering Paper Spray Ionization (EFSI) method for detecting compounds in unprocessed samples. A relatively rigid and electrically conductive copper filter was used as a substrate to insure sufficient and efficient sample-solvent extraction and to increase the conductivity for paper spraying. The method was demonstrated as applicable for indirect...
Through introducing octakis (3-mercaptopropyl) octasilsesquioxane (POSS-SH) synthesized in our lab to the prepolymerization solution containing stearyl acrylate (SA), 1,6-hexanediol ethoxylate diacrylate (HEDA) in the existence of porogenic solvents (tetrahydrofuran, 1,4-butanediol and 1-propanol), a POSS-containing hybrid monolithic column was fabricated via photo-initiated thiol-acrylate polymerization...
In this study, a novel air-assisted liquid-liquid microextraction (AALLME) method was developed for the HPLC determination of bisphenols migration from disposable plastic lunch box to contacting water. The AALLME was carried out in commercially-available medical plastic syringes with low-density extraction solvent (n-octanol), and the reaction of NaHCO3 and HCl was introduced to simultaneously induce...
In this work, aqueous biphasic systems (ABSs) composed of ionic liquids (ILs) and deep eutectic solvents (DESs) were developed and utilized to efficiently extract DNA for the first time. Four kinds of ILs/DESs were mainly constituted by betaine/carboxylic acid and betaine/carbohydrates respectively. While another DES ([TBAB][PPG400]) was formed by polypropylene glycol 400 (PPG 400) and tetrabutylammonium...
A pyrene-based colorimetric and fluorescent pH probe with large Stokes shift (145 nm) was developed. PNY afforded a pKa of 2.98 and responded linearly to minor pH changes within the range of 2.43 and 3.71. In addition, PNY could be used for detecting H+ with high sensitivity and selectivity, showing colorimetric and fluorometric dual-modal responses with short response time. Furthermore, PNY had good...
Here, a binding-induced nicking site reconstruction strategy has been fabricated for quantitative detection of membrane protein on living cell. Taking protein tyrosine kinase-7 (PTK7) as model analyst, first, an aptamer probe was designed with an aptamer sequence, a trigger sequence and a nicking site. In the absence of PTK7, the aptamer sequence could partially hybridize with the trigger sequence,...
In this paper, we introduced a new sensor for detecting sulfur mustard (SM) and its simulant through the functionalization of a rhodol chromophore with benzothiazole, followed by thionation of the spirolactam. The synthesized chemodosimeter (RHBT) exhibited an obvious green-yellow fluorescence enhancement and chromogenic change from colorless to fuchsia in the presence of SM and its simulant stimuli,...
Highly sensitive detection of proteins is essential to biomedical research as well as clinical diagnosis. However, usual detecting methods are complicated operating, time-costing and extensive label preparing. Here, we combined molecular beacon (MB) track mediated DNA walker and nicking enzyme assisted signal amplification method to develop a simple and ultrasensitive malachite green fluorescence...
Recently, great efforts have been made to use biosensors for the early diagnosis of cancer. Specifically, using a biomarker to detect H2O2 in physiological conditions is of great significance for understanding the signal transduction pathways and achieving early cancer diagnosis. In this work, we report an innovative H2O2 sensor that was fabricated by trimetallic AuPtPd nanocomposites platform on...
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