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Calcitriol, the hormonal form of vitamin D 3 , exerts immunomodulatory effects through the vitamin D 3 receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua. Nevertheless, the effects of calcitriol upon lymphocyte PRL have not been evaluated. Therefore, we investigated calcitriol effects upon PRL in resting and phytohemagglutinin-activated human peripheral...
Human placenta synthesizes and metabolizes 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 /calcitriol] through the activity of 25-hydroxyvitamin D 3 -1α-hydroxylase (CYP27B1) and 1,25(OH) 2 D 3 -24-hydroxylase (CYP24A1), the two key enzymes for Vitamin D metabolism. In this study, calcitriol rapidly generated intracellular cAMP accumulation in cultured human...
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