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The BC-rings of taxol can be synthesized using an intramolecular [5+2]-pyrylium ylide-alkene cyclization, followed by gem-methylcyclopropanation and reductive cleavage of the internal cyclopropane bond.
The A-ring of the taxanes is conveniently made from an ester-sulfone condensation, and is compatible with the 1-hydroxyl group, thus completing the synthesis of the ABC-rings.
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