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Tissue factor (TF) expression is progestin-enhanced in human endometrial stromal cells in vivo and in vitro. Previously, we showed that endometrial TF levels were respectively decreased and then increased in response to 6 months and 12 months of Norplant contraception. The progestin-dependence of TF expression in human endometrium prompted our evaluation of progesterone receptor (PR) levels in women...
During a 2-year period, we identified 19 postmenopausal (PMP) women with breast cancer treated postoperatively with 10 mg PO BID Tamoxifen (T) with endometrial histologically-proven diagnoses including: 1 atrophic, 2 proliferatives, 10 polyps, 4 polyps with CIS, hyperplasia, increased mitoses, or atypia, and 2 adenocarcinomas. Immunohistochemistry for endometrial ER and PR expression was performed...
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