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Objective The effect of epicatechin-3-gallate (ECG), a polyphenol that is present in green tea, on doxorubicin (DOX) cytotoxicity in H9C2 cardiomyocytes and its underlying mechanisms were investigated. Results Pretreatment with ECG (20 and 30 μM) significantly increased DOX-induced apoptosis to 16–18 % in H9C2 cardiomyocytes. The Bax/Bcl-2 ratio increased significantly after 1 h pretreatment with...
Objective Tea is the most consumed beverage in the world. (−)-Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, is effective in the prevention of several chronic diseases, and is marketed as part of many dietary supplements. We have now examined the myocardiotoxic effect of high doses of EGCG in mice. Results EGCG (500 and 1000 mg/kg·d) induced cardiac collagen synthesis and fibrosis-related...
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