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The aim of present study was to investigate the effects of isosteviol on hyperglycemia and hyperlipidemia in rats fed with high-fat emulsion (HFE).Hyperglycemia and hyperlipidemia in rats was induced by daily ingestion of HFE for 14days. Isosteviol (0.2, 1.0, or 5.0mg/kg/day) was orally administered for 7days, with rosiglitazone maleate (5.0mg/kg/day) used as the positive control. The levels of fasting...
This study was designed to assess the cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion (IR) injury and to explore the mechanism of action of the compound. Sprague Dawley rats were divided into 8 groups (n=10–12): a sham-operated control and 7 ischemia-reperfusion groups (IR control, 3 isosteviol pre-treated (0.5, 1.0 and 2.0 mg kg −1 ), ligustrazine pre-treated,...
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