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Objective
The aims of this study were as follows: 1) examine weight changes in older adults (mean age = 76 years) with type 2 diabetes and overweight or obesity during the COVID‐19 shutdown; and 2) compare the behavioral and psychosocial effects of the shutdown in those who had large weight losses (>5%), those who had small weight losses (2%‐5%), those who remained weight stable (±2%), or those...
Objective
Obesity is a growing global concern compounded by limited availability of effective treatment options. The SURMOUNT development program aims to evaluate the efficacy and safety of tirzepatide as an adjunct to lifestyle intervention compared with placebo on chronic weight management in adults with BMI ≥ 27 kg/m2 with or without type 2 diabetes.
Methods
The SURMOUNT program includes four...
Objective
This study aimed to measure the impact of the COVID‐19 pandemic on self‐reported life experiences in older adults with diabetes and obesity.
Methods
Participants were surveyed in 2020 regarding negative and positive impacts of the pandemic across domains of personal, social, and physical experiences. A cumulative negative risk index (a count of all reported negative impacts of 46 items)...
Objective
The Action for Health in Diabetes (Look AHEAD) study previously reported that intensive lifestyle intervention (ILI) reduced incident depressive symptoms and improved health‐related quality of life (HRQOL) over nearly 10 years of intervention compared with a control group (the diabetes support and education group [DSE]) in participants with type 2 diabetes and overweight or obesity. The...
Objective
This review synthesizes literature on changes in binge eating (BE) and loss of control eating (LOC) following weight loss and the association between BE/LOC and weight loss in children and adolescents.
Methods
A systematic literature search was conducted in PubMed, Scopus, and PsycInfo. Eligible studies included all peer‐reviewed journal articles of primary research that assessed BE/LOC...
Objective
This study aimed to assess the effects of exposures to food cues and stress on hunger and food intake and examine whether cue responses differ by weight status.
Methods
In a laboratory‐based experimental study, participants (n = 138) were exposed to stress, neutral, and food cues delivered using an individualized script‐driven imagery task on three separate days. After each cue exposure,...
Objective
This study evaluated weight changes after cessation of the 10‐year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2‐year observational period following termination of weight‐loss–maintenance counseling than would participants in the diabetes support and...
Objective
This exploratory analysis examined the effects of intensive behavioral therapy (IBT) for obesity (“IBT‐alone”), IBT plus liraglutide 3.0 mg/d (“IBT‐liraglutide”), and IBT plus liraglutide 3.0 mg/d plus 12 weeks of a portion‐controlled diet that provided 1,000 to 1,200 kcal/d (“Multicomponent”) on changes in food cravings, eating behaviors, and eating disorder psychopathology at 24 and 52...
Objective
This study examined end‐of‐trial health outcomes in participants in the Action for Health in Diabetes (Look AHEAD) trial who had bariatric surgery during the approximately 10‐year randomized intervention.
Methods
Data were obtained from the Look AHEAD public access database of 4,901 individuals with type 2 diabetes and overweight/obesity who were assigned to intensive lifestyle intervention...
Objective
This study aimed to assess whether alcohol consumption decreases during an intensive lifestyle intervention (ILI) and whether alcohol consumption is associated with weight loss among participants with overweight or obesity and type 2 diabetes.
Methods
Participants (n = 4,901) were from the Action for Health in Diabetes (Look AHEAD) study, a randomized controlled trial that compared an...
Objective
The Centers for Medicare and Medicaid Services (CMS) covers intensive behavioral therapy (IBT) for obesity. The efficacy, however, of the specific approach has never been evaluated in a randomized trial, as described here. The 1‐year trial also assessed whether the addition to IBT of liraglutide 3.0 mg would significantly increase weight loss and whether the provision of meal replacements...
Objective
The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight‐specific health‐related quality of life in a 66‐week trial.
Methods
Adults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14‐week intensive lifestyle intervention/low‐calorie diet (LCD) program were randomly...
Objective
Improving the maintenance of lost weight remains a critical challenge, which can be addressed by long‐term behavioral and/or pharmacological interventions.
Methods
This study investigated the efficacy of combined behavioral and pharmacological treatment in facilitating weight loss maintenance (WLM) in 137 adults (86.1% female; 68.6% black; BMI = 37.0 ± 5.6 kg/m2) who had lost ≥ 5% of...
Objective
This study aims to assess whether an intensive lifestyle intervention (ILI) for weight reduction precipitates binge eating (BE) and whether BE attenuates 4‐year weight loss among participants with type 2 diabetes and overweight or obesity.
Methods
Participants (N = 4,901) were from Look AHEAD, a randomized controlled trial that compared ILI to diabetes support and education (DSE). Annual...
Objective
To examine whether baseline chronic stress, morning cortisol, and other appetite‐related hormones (leptin, ghrelin, and insulin) predict future weight gain and food cravings in a naturalistic, longitudinal, 6‐month follow‐up study.
Methods
A prospective community cohort of 339 adults (age 29.1 ± 9.0 years; BMI = 26.7 ± 5.4 kg/m2; 56.9% female; 70.2% white) completed assessments at baseline...
Objective
Weight stigma is a chronic stressor that may increase cardiometabolic risk. Some individuals with obesity self‐stigmatize (i.e., weight bias internalization, WBI). No study to date has examined whether WBI is associated with metabolic syndrome.
Methods
Blood pressure, waist circumference, and fasting glucose, triglycerides, and high‐density lipoprotein cholesterol were measured at baseline...
Objective
A previous study reported that preoperative binge‐eating disorder (BED) did not attenuate weight loss at 12 months after bariatric surgery. This report extends the authors' prior study by examining weight loss at 24 months.
Methods
A modified intention‐to‐treat population was used to compare 24‐month changes in weight among 59 participants treated with bariatric surgery, determined preoperatively...
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