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Tissue engineering has the potential to support many surgical procedures by providing functional grafts upon demand. However, the production of tissues remains a complex process in which the regulatory role of specific physicochemical culture parameters is so far not completely understood. Today, by allowing controlled changes of specific environmental factors, bioreactor systems support the investigation...
Ausgedehnte osteochondrale Defekte erfordern eine Reparatur des Knorpels und des subchondralen Knochens. Wir erzeugten osteochondrales Ersatzgewebe mittels Tissue Engineering. 755mm groe standardisierte Defekte wurden im femoropatellaren Gleitlager von adulten Kaninchen erzeugt. Konstrukte, die in vitro aus Chondrozyten und abbaubarem Trgermaterial generiert wurden, wurden mit Collagraft als subchondralem...
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