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Background
Fetal aneuploidy risk increases with maternal age, but the majority of pregnancies complicated by trisomy 21 occur in younger women. It has been suggested that grandmaternal and/or paternal age may also play a role.
Objectives
To assess the association between grandmaternal and paternal age and trisomy 21.
Methods
For the grandmaternal assessments, we included all offspring with trisomy...
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