Search results for: John F Carlquist

Items from 1 to 20 out of 89 results

article

Impact of Testosterone Replacement Therapy on Myocardial Infarction, Stroke, and Death in Men With Low Testosterone Concentrations in an Integrated Health Care System

Jeffrey L. Anderson, Heidi T. May, Donald L. Lappé, Tami Bair, more

The American Journal of Cardiology > 2016 > 117 > 5 > 794-799

The aim of this study was to assess the effect of testosterone replacement therapy (TRT) on cardiovascular outcomes. Men (January 1, 1996, to December 31, 2011) with a low initial total testosterone concentration, a subsequent testosterone level, and >3 years of follow-up were studied. Levels were correlated with testosterone supplement use. The primary outcome was major adverse cardiovascular...

article

Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

John F. Carlquist, Stacey Knight, Richard M. Cawthon, Viet T. Le, more

Heart Rhythm > 2016 > 13 > 1 > 21-27

Atrial fibrillation (AF) diminishes quality of life and accounts for approximately one-third of all strokes. Studies have associated mitochondrial dysfunction with both AF and telomere length (TL).The purpose of this study was to test the hypothesis of a relationship between AF and TL.Blood was collected from consenting participants in the Intermountain Heart Collaborative Study (n = 3576) and DNA...

article

A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study

John F. Carlquist, David E. Moody, Stacey Knight, Eric G. Johnson, more

Molecular Diagnosis & Therapy > 2015 > 19 > 2 > 131-138

Background Methadone use and methadone-associated sudden cardiac death have increased dramatically. Prolongation of the QT interval of the cardiac cycle predisposes to arrhythmia and is common among methadone users. Objective We studied the relationship between pharmacogenetic variables and methadone metabolites and QT prolongation. Methods Blood was obtained on days 1, 7, and...

article

Secretory Phospholipase A2-IIA and Cardiovascular Disease

Michael V. Holmes, Tabassome Simon, Holly J. Exeter, Lasse Folkersen, more

Journal of the American College of Cardiology > 2013 > 62 > 21 > 1966-1976

This study sought to investigate the role of secretory phospholipase A₂ (sPLA₂)-IIA in cardiovascular disease.Higher circulating levels of sPLA₂-IIA mass or sPLA₂ enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal. A recent phase III clinical trial of an sPLA₂ inhibitor (varespladib) was stopped prematurely for...

article

Validation and Quantification of Genetic Determinants of Lipoprotein-a Levels and Predictive Value for Angiographic Coronary Artery Disease

Jeffrey L. Anderson, Stacey Knight, Heidi T. May, Benjamin D. Horne, more

The American Journal of Cardiology > 2013 > 112 > 6 > 799-804

Lipoprotein(a) (Lp[a]) has gained attention as a heritable coronary artery disease (CAD) risk factor and therapeutic target. Two genetic variants in the LPA gene have been reported to influence Lp(a) levels and increase CAD risk. The aim of this study was to prospectively test these variants for their associations with Lp(a) and CAD risk. Participants (n = 1,400) in the Intermountain Heart Collaborative...

article

Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden

Kenneth Chan, Riyaz S. Patel, Paul Newcombe, Christopher P. Nelson, more

Journal of the American College of Cardiology > 2013 > 61 > 9 > 957-970

This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD.Chromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque...

article

Relation of Routine, Periodic Fasting to Risk of Diabetes Mellitus, and Coronary Artery Disease in Patients Undergoing Coronary Angiography

Benjamin D. Horne, Joseph B. Muhlestein, Heidi T. May, John F. Carlquist, more

The American Journal of Cardiology > 2012 > 109 > 11 > 1558-1562

Previously we discovered that routine periodic fasting was associated with a lower prevalence of coronary artery disease (CAD). Other studies have shown that fasting increases longevity in animals. A hypothesis-generating analysis suggested that fasting may also associate with diabetes. This study prospectively tested whether routine periodic fasting is associated with diabetes mellitus (DM). Patients...

article

Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol

Brian H. Shirts, Michael T. Howard, Sandra J. Hasstedt, M. Nazeem Nanjee, more

Atherosclerosis > 2012 > 222 > 1 > 167-174

Vitamin D and serum lipid levels are risk factors for cardiovascular disease. We sought to determine if vitamin D (25OHD) interacts at established lipid loci potentially explaining additional variance in lipids.1060 individuals from Utah families were used to screen 14 loci for SNPs potentially interacting with dietary 25OHD on lipid levels. Identified putative interactions were evaluated for (1)...

article

Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population

Jason M. Lappé, Benjamin D. Horne, Svati H. Shah, Heidi T. May, more

Clinica Chimica Acta > 2011 > 412 > 23-24 > 2094-2099

Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal.In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RDW and its associations with inflammation, liver function, renal function, and body mass were assessed...

article

The intermountain risk score predicts incremental age-specific long-term survival and life expectancy

Benjamin D. Horne, Joseph B. Muhlestein, Donald L. Lappé, Kimberly D. Brunisholz, more

Translational Research > 2011 > 158 > 5 > 307-314

The Intermountain Risk Score (IMRS) encapsulates the mortality risk information from all components of the complete blood count (CBC) and basic metabolic profile (BMP), along with age. To individualize the IMRS more clearly, this study evaluated whether IMRS weightings for 1-year mortality predict age-specific survival over more than a decade of follow-up. Sex-specific 1-year IMRS values were calculated...

article

CHANGES IN TOTAL CHOLESTEROL AND OTHER CARDIAC RISK FACTORS DURING WATER-ONLY FASTING: TERTIARY OUTCOMES OF THE FEELGOOD TRIAL

Benjamin Davies Horne, Donald L. Lappé, Joseph B. Muhlestein, Abdallah G. Kfoury, more

Journal of the American College of Cardiology > 2011 > 57 > 14(S) > E498

article

Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare Population

Jeffrey L. Anderson, Heidi T. May, Benjamin D. Horne, Tami L. Bair, more

The American Journal of Cardiology > 2010 > 106 > 7 > 963-968

Vitamin D recently has been proposed to play an important role in a broad range of organ functions, including cardiovascular (CV) health; however, the CV evidence-base is limited. We prospectively analyzed a large electronic medical records database to determine the prevalence of vitamin D deficiency and the relation of vitamin D levels to prevalent and incident CV risk factors and diseases, including...

article

Replication of Genome-Wide Association of the PTHLH-KLHDC5 Locus with Peripartum Cardiomyopathy

Benjamin D. Horne, Kismet D. Rasmusson, Rami Alharethi, Deborah Budge, more

Journal of Cardiac Failure > 2010 > 16 > 8 Supplement > S38

article

Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease

Jeffrey L. Anderson, Benjamin D. Horne, Nicola J. Camp, Joseph B. Muhlestein, more

American Heart Journal > 2010 > 160 > 2 > 250-256.e3

The aim of this study is to discover common variants in 6 lipid metabolic genes and construct and validate a genetic risk score (GRS) based on the joint effects of genetic variants in multiple genes from lipid and other pathobiologic pathways.Explaining the genetic basis of coronary artery disease (CAD) is incomplete. Discovery and aggregation of genetic variants from multiple pathways may advance...

article

Antilipidemic adherence post-coronary artery disease diagnosis among those with and without an ICD-9 diagnosis of depression

Heidi T. May, Xiaoming Sheng, A. Peter Catinella, Benjamin D. Horne, more

Journal of Psychosomatic Research > 2010 > 69 > 2 > 169-174

An association between depression and coronary artery disease (CAD) is well established. Poor adherence to cardiac treatments may be one way depression could contribute to the increased risk of coronary events among depressed patients. We sought to evaluate whether adherence to antilipid medication, a therapy shown to be beneficial in secondary prevention of coronary events, differs among CAD patients...

article

Association of vitamin D levels with incident depression among a general cardiovascular population

Heidi T. May, Tami L. Bair, Donald L. Lappé, Jeffrey L. Anderson, more

American Heart Journal > 2010 > 159 > 6 > 1037-1043

Depression is associated with cardiovascular (CV) disease, and it has been hypothesized that vitamin (vit)D deficiency may be associated with depression and a contributing factor to excess CV events. Therefore, we evaluated whether there is an association between vitD and incident depression among a CV population.Patients (N = 7,358) ≥50 years of age, with a CV diagnosis (coronary artery disease,...

article

WARFARIN DOSING ALGORITHM REFINEMENTS AFTER 7-9 DAYS OF THERAPY BASED ON PHARMACOGENETIC, PHARMACOKINETIC, CLINICAL, AND LABORATORY DATA

Benjamin D. Horne, Petra A. Lenzini, Mia Wadelius, Andrea L. Jorgensen, more

Journal of the American College of Cardiology > 2010 > 55 > 10(S) > A130.E1218

article

SUPPLEMENTING DEFICIENT VITAMIN D LEVELS IS ASSOCIATED WITH REDUCED CARDIOVASCULAR RISK

Tami Bair, Joseph B. Muhlestein, Heidi T. May, Benjamin D. Horne, more

Journal of the American College of Cardiology > 2010 > 55 > 10(S) > A59.E564

article

APOLIPOPROTEIN A1 PREDICTS FUTURE DEATH AND MYOCARDIAL INFARCTION IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

Heidi Thomas May, Krishnaji R. Kulkarni, Benjamin D. Horne, Jeffrey L. Anderson, more

Journal of the American College of Cardiology > 2010 > 55 > 10(S) > A55.E521

article

LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 PREDICTION OF CORONARY ARTERY DISEASE DIAGNOSIS AMONG PATIENTS WITH DIFFERING NUMBERS OF RISK FACTORS

Farangis Lavasani, Heidi T. May, Benjamin D. Horne, Jeffrey L. Anderson, more

Journal of the American College of Cardiology > 2010 > 55 > 10(S) > A165.E1543

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INFONA - science communication portal

Search results for: John F Carlquist

Impact of Testosterone Replacement Therapy on Myocardial Infarction, Stroke, and Death in Men With Low Testosterone Concentrations in an Integrated Health Care System

Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study

Secretory Phospholipase A2-IIA and Cardiovascular Disease

Validation and Quantification of Genetic Determinants of Lipoprotein-a Levels and Predictive Value for Angiographic Coronary Artery Disease

Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden

Relation of Routine, Periodic Fasting to Risk of Diabetes Mellitus, and Coronary Artery Disease in Patients Undergoing Coronary Angiography

Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol

Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population

The intermountain risk score predicts incremental age-specific long-term survival and life expectancy

CHANGES IN TOTAL CHOLESTEROL AND OTHER CARDIAC RISK FACTORS DURING WATER-ONLY FASTING: TERTIARY OUTCOMES OF THE FEELGOOD TRIAL

Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare Population

Replication of Genome-Wide Association of the PTHLH-KLHDC5 Locus with Peripartum Cardiomyopathy

Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease

Antilipidemic adherence post-coronary artery disease diagnosis among those with and without an ICD-9 diagnosis of depression

Association of vitamin D levels with incident depression among a general cardiovascular population

WARFARIN DOSING ALGORITHM REFINEMENTS AFTER 7-9 DAYS OF THERAPY BASED ON PHARMACOGENETIC, PHARMACOKINETIC, CLINICAL, AND LABORATORY DATA

SUPPLEMENTING DEFICIENT VITAMIN D LEVELS IS ASSOCIATED WITH REDUCED CARDIOVASCULAR RISK

APOLIPOPROTEIN A1 PREDICTS FUTURE DEATH AND MYOCARDIAL INFARCTION IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 PREDICTION OF CORONARY ARTERY DISEASE DIAGNOSIS AMONG PATIENTS WITH DIFFERING NUMBERS OF RISK FACTORS

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