Search results for: Kilian M. Pohl

Items from 1 to 20 out of 45 results

article

Multi‐level prediction of substance use: Interaction of white matter integrity, resting‐state connectivity and inhibitory control measured repeatedly in every‐day life

Valentine Chirokoff, Kilian M. Pohl, Sylvie Berthoz, Melina Fatseas, more

Substance use disorders are characterized by inhibition deficits related to disrupted connectivity in white matter pathways, leading via interaction to difficulties in resisting substance use. By combining neuroimaging with smartphone‐based ecological momentary assessment (EMA), we questioned how biomarkers moderate inhibition deficits to predict use. Thus, we aimed to assess white matter integrity...

article

Multi‐atlas thalamic nuclei segmentation on standard T1‐weighed MRI with application to normal aging

Adolf Pfefferbaum, Edith V. Sullivan, Natalie M. Zahr, Kilian M. Pohl, more

Human Brain Mapping > 44 > 2 > 612 - 628

Specific thalamic nuclei are implicated in healthy aging and age‐related neurodegenerative diseases. However, few methods are available for robust automated segmentation of thalamic nuclei. The threefold aims of this study were to validate the use of a modified thalamic nuclei segmentation method on standard T1 MRI data, to apply this method to quantify age‐related volume declines, and to test functional...

article

Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls

Qingyu Zhao, Edith V. Sullivan, Eva M. Műller‐Oehring, Nicolas Honnorat, more

Addiction Biology > 26 > 2 > n/a - n/a

Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional networks in youth drinking below diagnostic threshold for alcohol use disorder (AUD). Based on the 3‐year, annually acquired, longitudinal resting‐state...

article

Jacobian Mapping Reveals Converging Brain Substrates of Disruption and Repair in Response to Ethanol Exposure and Abstinence in 2 Strains of Rats

Qingyu Zhao, Kilian M. Pohl, Edith V. Sullivan, Adolf Pfefferbaum, more

Alcoholism: Clinical and Experimental Research > 45 > 1 > 92 - 104

Background In a previous study using Jacobian mapping to evaluate the morphological effects on the brain of binge (4‐day) intragastric ethanol (EtOH) on wild‐type Wistar rats, we reported reversible thalamic shrinkage and lateral ventricular enlargement, but persistent superior and inferior colliculi shrinkage in response to binge EtOH treatment. Methods Herein, we used similar voxel‐based comparisons...

article

Accelerated aging and motor control deficits are related to regional deformation of central cerebellar white matter in alcohol use disorder

Qingyu Zhao, Adolf Pfefferbaum, Simon Podhajsky, Kilian M. Pohl, more

Addiction Biology > 25 > 3 > n/a - n/a

The World Health Organization estimates a 12‐month prevalence rate of 8+% for an alcohol use disorder (AUD) diagnosis in people age 15 years and older in the United States and Europe, presenting significant health risks that have the potential of accelerating age‐related functional decline. According to neuropathological studies, white matter systems of the cerebellum are vulnerable to chronic alcohol...

article

Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV

Natalie M. Zahr, Edith V. Sullivan, Kilian M. Pohl, Adolf Pfefferbaum, more

Human Brain Mapping > 41 > 5 > 1351 - 1361

Volumes of thalamic nuclei are differentially affected by disease‐related processes including alcoholism and human immunodeficiency virus (HIV) infection. This MRI study included 41 individuals diagnosed with alcohol use disorders (AUD, 12 women), 17 individuals infected with HIV (eight women), and 49 healthy controls (24 women) aged 39 to 75 years. A specialized, high‐resolution acquisition protocol...

article

Central Nervous System Correlates of “Objective” Neuropathy in Alcohol Use Disorder

Natalie M. Zahr, Kilian M. Pohl, Adolf Pfefferbaum, Edith V. Sullivan

Alcoholism: Clinical and Experimental Research > 43 > 10 > 2144 - 2152

Background Among the neurological consequences of alcoholism is peripheral neuropathy. Relative to human immunodeficiency virus (HIV) or diabetes‐related neuropathies, neuropathy associated with alcohol use disorders (AUD) is understudied. In both the diabetes and HIV literature, emerging evidence supports a central nervous system (CNS) component to peripheral neuropathy. Methods In seeking a central...

article

Relations between cognitive and motor deficits and regional brain volumes in individuals with alcoholism

Rosemary Fama, Anne-Pascale Berre, Stephanie A. Sassoon, Natalie M. Zahr, more

Brain Structure and Function > 2019 > 224 > 6 > 2087-2101

Despite the common co-occurrence of cognitive impairment and brain structural deficits in alcoholism, demonstration of relations between regional gray matter volumes and cognitive and motor processes have been relatively elusive. In pursuit of identifying brain structural substrates of impairment in alcoholism, we assessed executive functions (EF), episodic memory (MEM), and static postural balance...

article

Longitudinally consistent estimates of intrinsic functional networks

Qingyu Zhao, Dongjin Kwon, Eva M. Müller‐Oehring, Anne‐Pascale Le Berre, more

Human Brain Mapping > 40 > 8 > 2511 - 2528

Increasing numbers of neuroimaging studies are acquiring data to examine changes in brain architecture by investigating intrinsic functional networks (IFN) from longitudinal resting‐state functional MRI (rs‐fMRI). At the subject level, these IFNs are determined by cross‐sectional procedures, which neglect intra‐subject dependencies and result in suboptimal estimates of the networks. Here, a novel...

article

Distribution of brain iron accrual in adolescence: Evidence from cross‐sectional and longitudinal analysis

Eric T. Peterson, Dongjin Kwon, Beatriz Luna, Bart Larsen, more

Human Brain Mapping > 40 > 5 > 1480 - 1495

To track iron accumulation and location in the brain across adolescence, we repurposed diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) data acquired in 513 adolescents and validated iron estimates with quantitative susceptibility mapping (QSM) in 104 of these subjects. DTI and fMRI data were acquired longitudinally over 1 year in 245 male and 268 female, no‐to‐low alcohol‐consuming...

article

Dissociable Contributions of Precuneus and Cerebellum to Subjective and Objective Neuropathy in HIV

Natalie M. Zahr, Kilian M. Pohl, Adolf Pfefferbaum, Edith V. Sullivan

Journal of Neuroimmune Pharmacology > 2019 > 14 > 3 > 436-447

Neuropathy, typically diagnosed by the presence of either symptoms or signs of peripheral nerve dysfunction, remains a frequently reported complication in the antiretroviral (ART)-treated HIV population. This study was conducted in 109 healthy controls and 57 HIV-infected individuals to investigate CNS regions associated with neuropathy. An index of objective neuropathy was computed based on 4 measures:...

article

Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder

Edith V. Sullivan, Natalie M. Zahr, Manojkumar Saranathan, Kilian M. Pohl, more

NeuroImage: Clinical > 2019 > 24 > C

Recent advances in robust and reliable methods of MRI-derived cerebellar lobule parcellation volumetry present the opportunity to assess effects of Alcohol Use Disorder (AUD) on selective cerebellar lobules and relations with indices of nutrition and motor functions. In pursuit of this opportunity, we analyzed high-resolution MRI data acquired in 24 individuals with AUD and 20 age- and sex-matched...

article

The mediating role of cortical thickness and gray matter volume on sleep slow-wave activity during adolescence

Aimée Goldstone, Adrian R. Willoughby, Massimiliano Zambotti, Peter L. Franzen, more

Brain Structure and Function > 2018 > 223 > 2 > 669-685

During the course of adolescence, reductions occur in cortical thickness and gray matter (GM) volume, along with a 65% reduction in slow-wave (delta) activity during sleep (SWA) but empirical data linking these structural brain and functional sleep differences, is lacking. Here, we investigated specifically whether age-related differences in cortical thickness and GM volume and cortical thickness...

article

Eveningness and Later Sleep Timing Are Associated with Greater Risk for Alcohol and Marijuana Use in Adolescence: Initial Findings from the National Consortium on Alcohol and Neurodevelopment in Adolescence Study

Brant P. Hasler, Peter L. Franzen, Massimiliano Zambotti, Devin Prouty, more

Alcoholism: Clinical and Experimental Research > 41 > 6 > 1154 - 1165

Background Abundant cross‐sectional evidence links eveningness (a preference for later sleep–wake timing) and increased alcohol and drug use among adolescents and young adults. However, longitudinal studies are needed to examine whether eveningness is a risk factor for subsequent alcohol and drug use, particularly during adolescence, which is marked by parallel peaks in eveningness and risk for the...

article

Effects of prior testing lasting a full year in NCANDA adolescents: Contributions from age, sex, socioeconomic status, ethnicity, site, family history of alcohol or drug abuse, and baseline performance

Edith V. Sullivan, Ty Brumback, Susan F. Tapert, Devin Prouty, more

Developmental Cognitive Neuroscience > 2017 > 24 > C > 72-83

Longitudinal study provides a robust method for tracking developmental trajectories. Yet inherent problems of retesting pose challenges in distinguishing biological developmental change from prior testing experience. We examined factors potentially influencing change scores on 16 neuropsychological test composites over 1year in 568 adolescents in the National Consortium on Alcohol and NeuroDevelopment...

article

Computing group cardinality constraint solutions for logistic regression problems

Yong Zhang, Dongjin Kwon, Kilian M. Pohl

Medical Image Analysis > 2017 > 35 > C > 58-69

We derive an algorithm to directly solve logistic regression based on cardinality constraint, group sparsity and use it to classify intra-subject MRI sequences (e.g. cine MRIs) of healthy from diseased subjects. Group cardinality constraint models are often applied to medical images in order to avoid overfitting of the classifier to the training data. Solutions within these models are generally determined...

article

Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification

Yong Zhang, Dongjin Kwon, Pardis Esmaeili‐Firidouni, Adolf Pfefferbaum, more

Human Brain Mapping > 37 > 12 > 4523 - 4538

HIV‐Associated Neurocognitive Disorder (HAND) is the most common constellation of cognitive dysfunctions in chronic HIV infected patients age 60 or older in the U.S. Only few published methods assist in distinguishing HAND from other forms of age‐associated cognitive decline, such as Mild Cognitive Impairment (MCI). In this report, a data‐driven, nonparameteric model to identify morphometric patterns...

chapter

Active Mean Fields: Solving the Mean Field Approximation in the Level Set Framework

Kilian M. Pohl, Ron Kikinis, William M. Wells

Lecture Notes in Computer Science > Information Processing in Medical Imaging > Segmentation > 26-37

We describe a new approach for estimating the posterior probability of tissue labels. Conventional likelihood models are combined with a curve length prior on boundaries, and an approximate posterior distribution on labels is sought via the Mean Field approach. Optimizing the resulting estimator by gradient descent leads to a level set style algorithm where the level set functions are the logarithm-of-odds...

article

Structural brain anomalies in healthy adolescents in the NCANDA cohort: relation to neuropsychological test performance, sex, and ethnicity

Edith V. Sullivan, Barton Lane, Dongjin Kwon, M. J. Meloy, more

Brain Imaging and Behavior > 2017 > 11 > 5 > 1302-1315

Structural MRI of volunteers deemed “normal” following clinical interview provides a window into normal brain developmental morphology but also reveals unexpected dysmorphology, commonly known as “incidental findings.” Although unanticipated, these anatomical findings raise questions regarding possible treatment that could even ultimately require neurosurgical intervention, which itself carries significant...

chapter

Shape Based Segmentation of Anatomical Structures in Magnetic Resonance Images

Kilian M. Pohl, John Fisher, Ron Kikinis, W. Eric L. Grimson, more

Lecture Notes in Computer Science > Computer Vision for Biomedical Image Applications > 489-498

Standard image based segmentation approaches perform poorly when there is little or no contrast along boundaries of different regions. In such cases, segmentation is largely performed manually using prior knowledge of the shape and relative location of the underlying structures combined with partially discernible boundaries. We present an automated approach guided by covariant shape deformations of...

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INFONA - science communication portal

Search results for: Kilian M. Pohl

Multi‐level prediction of substance use: Interaction of white matter integrity, resting‐state connectivity and inhibitory control measured repeatedly in every‐day life

Multi‐atlas thalamic nuclei segmentation on standard T1‐weighed MRI with application to normal aging

Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls

Jacobian Mapping Reveals Converging Brain Substrates of Disruption and Repair in Response to Ethanol Exposure and Abstinence in 2 Strains of Rats

Accelerated aging and motor control deficits are related to regional deformation of central cerebellar white matter in alcohol use disorder

Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV

Central Nervous System Correlates of “Objective” Neuropathy in Alcohol Use Disorder

Relations between cognitive and motor deficits and regional brain volumes in individuals with alcoholism

Longitudinally consistent estimates of intrinsic functional networks

Distribution of brain iron accrual in adolescence: Evidence from cross‐sectional and longitudinal analysis

Dissociable Contributions of Precuneus and Cerebellum to Subjective and Objective Neuropathy in HIV

Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder

The mediating role of cortical thickness and gray matter volume on sleep slow-wave activity during adolescence

Eveningness and Later Sleep Timing Are Associated with Greater Risk for Alcohol and Marijuana Use in Adolescence: Initial Findings from the National Consortium on Alcohol and Neurodevelopment in Adolescence Study

Effects of prior testing lasting a full year in NCANDA adolescents: Contributions from age, sex, socioeconomic status, ethnicity, site, family history of alcohol or drug abuse, and baseline performance

Computing group cardinality constraint solutions for logistic regression problems

Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification

Active Mean Fields: Solving the Mean Field Approximation in the Level Set Framework

Structural brain anomalies in healthy adolescents in the NCANDA cohort: relation to neuropsychological test performance, sex, and ethnicity

Shape Based Segmentation of Anatomical Structures in Magnetic Resonance Images

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