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Aim
Endogenous dynorphin signaling via kappa opioid receptors (KORs) plays a key role in producing the depressive and aversive consequences of stress. We investigated the behavioral effects of the dynorphin/KOR system in the ventral pallidum (VP) and studied the underlying mechanisms.
Methods
To investigate the effects of dynorphin on the VP, we conducted behavioral experiments after microinjection...
Aim
The sodium/hydrogen exchanger 2 (NHE2) is an intestinal acid extruder with crypt‐predominant localization and unresolved physiological significance. Our aim was to decipher its role in colonic epithelial cell proliferation, differentiation and electrolyte transport.
Methods
Alterations induced by NHE2‐deficiency were addressed in murine nhe2−/− and nhe2+/+ colonic crypts and colonoids, and...
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