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Functional activation of GTP-binding (G) proteins coupled with metabotropic glutamate receptors was evaluated in rat brain membranes. l-Glutamate stimulated the high-affinity GTPase activity in cerebral cortical, hippocampal, and striatal membranes with a mean concentration eliciting a half-maximal response (EC 50 ) of 4.8, 1.6, and 4.9 μM, respectively. The enzyme activity in cerebral...
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