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Microsomal epoxide hydrolase (mEH) is a bifunctional protein that plays a central role in carcinogen metabolism and is also able to mediate the sodium-dependent uptake of bile acids into hepatocytes. Studies have identified a subject (S-1) with extremely elevated serum bile salt levels in the absence of observable hepatocellular injury, suggesting a defect in bile acid uptake. In this individual,...
Patients with congenital lack of I - transport do not accumulate I - in their thyroids, often resulting in severe hypothyroidism. A single amino acid substitution in the thyroid Na + /I - symporter (NIS), proline replacing threonine at position 354 (T354P), was recently identified as the cause of this condition in two independent patients . Here we report that the lack...
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