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Background
Nivolumab demonstrated durable responses and safety in patients with hepatocellular carcinoma (HCC) with Child‐Pugh class A cirrhosis in the CheckMate 040 trial, with rates of hepatotoxicity that were similar to those of non‐HCC populations. To the authors' knowledge, the safety and efficacy of nivolumab has not been established in patients with Child‐Pugh class B (CPB) cirrhosis, a population...
BACKGROUNDStatins are cholesterol‐lowering medications with pleiotropic effects, including alterations in growth signaling, as well as immunomodulatory and anti‐inflammatory effects that may alter cancer risk. Evidence from previous epidemiologic studies is inconsistent about whether statin use is associated with a reduced risk of pancreatic cancer (PC).
METHODSPatients with confirmed diagnoses of...
BACKGROUND:Screening and early diagnosis tools are lacking for pancreatic adenocarcinoma; most patients are diagnosed with metastatic disease. Autoantibodies to tumor‐associated antigens (TAAs) can be present months to years before diagnosis and hold promise as biomarkers for early detection.
METHODS:TAAs to pancreatic cancer autoantibodies CTDSP1 (carboxy‐terminal domain, RNA polymerase II, polypeptide...
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