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Künstliche Modelle der natürlichen SNARE‐Proteine, bestehend aus den nativen Linkern (hellblau/grau) und Transmembrandomänen (TMDs) von Synaptobrevin (Syb, violett) und Syntaxin‐1A (Sx, orange) sowie einem Peptidnucleinsäure(PNA)‐Erkennungsmotiv, haben die Möglichkeit zur antiparallelen (siehe Bild) oder parallelen Orientierung der interagierenden Stränge. Die Systeme induzieren die Hemi‐ und zum...
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