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Polymethoxyflavones (PMFs), such as nobiletin and tangeretin, have a high cellular uptake rate, on account of their hydrophobicity. Nobiletin has been shown to down-regulate inflammatory gene expression, and is thus considered a promising anti-inflammatory and anti-carcinogenic agent. Most proteins known to be affected by PMFs are cell cycle regulators and kinases. In the present study, we demonstrate...
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