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Due to its high metastatic potential, malignant melanoma is one of the deadliest skin cancers. In melanoma as well as in other cancers, acidification of the tumor microenvironment (=TME, inverse pH‐gradient) is a well‐known driver of tumor progression and metastasis. Membrane‐bound receptors, such as the proton‐sensitive GPCR (pH‐GPCR) GPR4, are considered as potential initiators of the signalling...
The present study describes the detection and localization of silica particles with diameters between 2 µm and 150 nm within the cytoplasm of mammalian cells by means of ToF‐SIMS 3D analysis. The particles were selected as model objects for non‐luminescent, unlabeled particles that are hard to localize by other experimental approaches. ToF‐SIMS analysis proved the uptake of the particles into the...
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