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We present recent results on biochips slides with high fluorescence efficiency and their associated readout systems. To obtain the full performance made possible by such slides, the chemical surface functionalization has to be improved, as formerly unobservable defects of the functionalization are now made observable through the improved efficiency. The systems are based on the integration of the...
Les saccharides jouent un rôle essentiel dans de nombreux mécanismes biologiques, physiologiques et pathologiques. La compréhension de l’ensemble des interactions saccharides/protéines, saccharides/saccharides et saccharides/ADN (la glycomique) est une étape incontournable pour les avancées futures tant du point de vue fondamentale que pour le développement de nouvelles voies thérapeutiques.Les principaux...
The present review describes the multidisciplinary approach followed by the Chemistry and Nanobiotechnology group of INL since ten years, to develop a complete technological platform dedicated to molecular diagnosis using biochips and biosensors. This work, replaced in an international context, illustrates the importance to identify the various pitfalls inherent to molecular analysis throughout an...
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