Cell Metabolism

Items from 1 to 20 out of 2,576 results

article

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

Barbara B. Kahn, Thierry Alquier, David Carling, D. Grahame Hardie

Cell Metabolism > 2005 > 1 > 1 > 15-25

The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status, and recent data demonstrate that it also plays a critical role in systemic energy balance. AMPK integrates nutritional and hormonal signals in peripheral tissues and the hypothalamus. It mediates effects of adipokines (leptin, adiponectin, and possibly resistin) in regulating food intake, body...

article

The fat and thin of lipin

Marc L. Reitman

Cell Metabolism > 2005 > 1 > 1 > 5-6

Mutations in the Lpin1 gene (encoding lipin) cause the lipodystrophy (adipose tissue deficiency) of the fld mouse, but the underlying mechanism has been unclear. In this issue of Cell Metabolism, Phan and Reue (2005) show that overexpression of lipin in either muscle or adipose tissue increases adiposity. Interestingly, mice overexpressing lipin in muscle are insulin resistant, while those overexpressing...

article

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver

Hiroshi Kuriyama, Guosheng Liang, Luke J. Engelking, Jay D. Horton, more

Cell Metabolism > 2005 > 1 > 1 > 41-51

The escort protein SCAP transports SREBPs from ER to Golgi where the active domains are released to activate genes for fatty acid (FA) and cholesterol synthesis. Mice with conditional SCAP deficiency in liver (L-Scap ⁻ ) manifest marked reductions in hepatic lipid synthesis. Here, we show that the decreased FA synthesis in liver is balanced by an equal increase in nonhepatic tissues, primarily...

article

The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

Roberto Coppari, Masumi Ichinose, Charlotte E. Lee, Abigail E. Pullen, more

Cell Metabolism > 2005 > 1 > 1 > 63-72

Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate nucleus (ARH) has been proposed as an important site of leptin action. To assess the physiological significance of leptin signaling in the ARH, we used mice homozygous for a FLPe-reactivatable, leptin receptor null allele (Lepr ^neo/neo mice). Similar to Lepr ^db/db mice, these mice are obese, hyperglycemic,...

article

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Kensuke Tsushima, more

Cell Metabolism > 2005 > 1 > 1 > 27-39

Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in the pathogenesis of cardiovascular disease. Here, we show that neonatal heterozygous KLF5 knockout mice exhibit a marked deficiency in white adipose tissue development, suggesting that KLF5 is also required for adipogenesis. In 3T3-L1 preadipocytes, KLF5 expression was induced at an early stage of differentiation,...

article

A new home for metabolic research

Charlotte Wang

Cell Metabolism > 2005 > 1 > 1 > 1

article

Cell Metabolism: Why, and why now?

Michael Brown, Jeffrey Flier, Jeffrey Friedman, Joseph Goldstein, more

Cell Metabolism > 2005 > 1 > 1 > 3

article

CAR: Three new models for a problem child

David D. Moore

Cell Metabolism > 2005 > 1 > 1 > 6-8

By comparison with its older and better-behaved cousins in the nuclear receptor superfamily, CAR (NR1I3) has always been an oddball. Three new crystal structures recently described in Molecular Cell reveal the molecular basis for some of its bad habits (Xu et al., 2004; Suino et al., 2004; Shan et al., 2004).

article

A brain-liver circuit regulates glucose homeostasis

Alessandro Pocai, Silvana Obici, Gary J. Schwartz, Luciano Rossetti

Cell Metabolism > 2005 > 1 > 1 > 53-61

Increased glucose production (GP) is the major determinant of fasting hyperglycemia in diabetes mellitus. Previous studies suggested that lipid metabolism within specific hypothalamic nuclei is a biochemical sensor for nutrient availability that exerts negative feedback on GP. Here we show that central inhibition of fat oxidation leads to selective activation of brainstem neurons within the nucleus...

article

Lipin, a lipodystrophy and obesity gene

Jack Phan, Karen Reue

Cell Metabolism > 2005 > 1 > 1 > 73-83

Lipodystrophy and obesity represent extreme and opposite ends of the adiposity spectrum and have typically been attributed to alterations in the expression or function of distinct sets of genes. We previously demonstrated that lipin deficiency impairs adipocyte differentiation and causes lipodystrophy in the mouse. Using two different tissue-specific lipin transgenic mouse strains, we now demonstrate...

article

Why Syndrome X? From Harold Himsworth to the Insulin Resistance Syndrome

Gerald M. Reaven

Cell Metabolism > 2005 > 1 > 1 > 9-14

Although the concept of Syndrome X was introduced in the Banting Medal address of 1988 (Reaven, 1988), the notion that led to its genesis had started approximately 50 years earlier. In this short history, an attempt will be made to trace the two paths of scientific discovery that were formally merged in New Orleans in 1988 to form the scientific foundation of Syndrome X. In addition, the developments...

article

Krox20 stimulates adipogenesis via C/EBPβ-dependent and -independent mechanisms

Zhu Chen, Javier I. Torrens, Ashim Anand, Bruce M. Spiegelman, more

Cell Metabolism > 2005 > 1 > 2 > 93-106

Krox20 is a zinc finger-containing transcription factor that is abundantly expressed in adipose tissue. However, its role in fat cell differentiation has not been established. In cultured 3T3-L1 cells, Krox20 is rapidly induced by serum stimulation. Overexpression of Krox20 in both 3T3-L1 preadipocytes and multipotent NIH3T3 cells promotes adipogenesis in a hormone-dependent manner. Conversely, RNAi-mediated...

article

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes

Kazuhisa Maeda, Haiming Cao, Keita Kono, Cem Z. Gorgun, more

Cell Metabolism > 2005 > 1 > 2 > 107-119

Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism. Mice lacking aP2 and mal1 exhibited a striking phenotype with strong protection from diet-induced...

article

“Corination” of the proANP converting enzyme

Lincoln R. Potter

Cell Metabolism > 2005 > 1 > 2 > 88-90

The membrane protease, corin, has been shown to be the proatrial natriuretic peptide (ANP)-converting enzyme. Like mice lacking ANP, corin-deficient animals are hypertensive and have cardiac hypertrophy.

article

Getting fat: Two new players in molecular adipogenesis

Frank J. Gonzalez

Cell Metabolism > 2005 > 1 > 2 > 85-86

A transcription factor cascade drives adipogenesis. Two new members of this cascade have been uncovered—Kruppel-like factor 5 (KLF5), which is induced by C/EBPβ and δ and acts in concert with C/EBPα, β, and δ to activate PPARγ2 expression, and Krox20, which is upstream of C/EBPβ expression and one of the earliest factors induced during adipogenesis.

article

SHIPing news: A new way to keep your weight down

Morris J. Birnbaum

Cell Metabolism > 2005 > 1 > 2 > 90-92

Almost always, obesity is an obligate prerequisite for the development of type 2 diabetes mellitus. Loss of a well-known lipid phosphatase appears to prevent insulin-resistant diabetes in mice by removal of a positive regulator of adiposity.

article

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

Matthew A. Kennedy, Gabriel C. Barrera, Kotoka Nakamura, Ángel Baldán, more

Cell Metabolism > 2005 > 1 > 2 > 121-131

Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL. Targeted disruption of Abcg1 in mice has no effect on plasma lipids but results in massive accumulation of both neutral lipids and phospholipids in hepatocytes and in macrophages within multiple tissues following administration...

article

ABCG1: How critical for cholesterol transport?

Neil S. Shachter

Cell Metabolism > 2005 > 1 > 2 > 87-88

In the current issue of Cell Metabolism, Kennedy et al. (2005) have extended our understanding of the ABCG1 transporter. Their studies demonstrate that, at least in macrophages, ABCG1 is responsible for much of the cholesterol efflux that utilizes mature HDL as an acceptor.

article

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

Brian N. Finck, Carlos Bernal-Mizrachi, Dong Ho Han, Trey Coleman, more

Cell Metabolism > 2005 > 1 > 2 > 133-144

The role of the peroxisome proliferator-activated receptor-α (PPARα) in the development of insulin-resistant diabetes was evaluated using gain- and loss-of-function approaches. Transgenic mice overexpressing PPARα in muscle (MCK-PPARα mice) developed glucose intolerance despite being protected from diet-induced obesity. Conversely, PPARα null mice were protected from diet-induced insulin resistance...

article

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly

Yih-Woei C. Fridell, Adolfo Sánchez-Blanco, Brian A. Silvia, Stephen L. Helfand

Cell Metabolism > 2005 > 1 > 2 > 145-152

The oxidative stress hypothesis of aging predicts that a reduction in the generation of mitochondrial reactive oxygen species (ROS) will decrease oxidative damage and extend life span. Increasing mitochondrial proton leak-dependent state 4 respiration by increasing mitochondrial uncoupling is an intervention postulated to decrease mitochondrial ROS production. When human UCP2 (hUCP2) is targeted to...

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FreeMarker template error (HTML_DEBUG mode; use RETHROW in production!)


Java method "org.springframework.web.servlet.support.RequestContext.getMessage(String)" threw an exception when invoked on org.springframework.web.servlet.support.RequestContext object "org.springframework.web.servlet.support.RequestContext@653ac433"; see cause exception in the Java stack trace.

----
FTL stack trace ("~" means nesting-related):
	- Failed at: ${springMacroRequestContext.getMessag...  [in template "META-INF/freemarker-templates/spring.ftl" in macro "message" at line 28, column 22]
	- Reached through: @spring.message "portal.searchResult...  [in template "META-INF/freemarker-templates/portal/search/facets.ftl" at line 149, column 33]
----

Java stack trace (for programmers):
----
freemarker.core._TemplateModelException: [... Exception message was already printed; see it above ...]
	at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:289)
	at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:261)
	at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:65)
	at freemarker.core.MethodCall._eval(MethodCall.java:65)
	at freemarker.core.Expression.eval(Expression.java:81)
	at freemarker.core.DollarVariable.calculateInterpolatedStringOrMarkup(DollarVariable.java:96)
	at freemarker.core.DollarVariable.accept(DollarVariable.java:59)
	at freemarker.core.Environment.visit(Environment.java:363)
	at freemarker.core.Environment.invoke(Environment.java:715)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:369)
	at freemarker.core.IteratorBlock$IterationContext.executedNestedContentForCollOrSeqListing(IteratorBlock.java:316)
	at freemarker.core.IteratorBlock$IterationContext.executeNestedContent(IteratorBlock.java:272)
	at freemarker.core.IteratorBlock$IterationContext.accept(IteratorBlock.java:243)
	at freemarker.core.Environment.visitIteratorBlock(Environment.java:596)
	at freemarker.core.IteratorBlock.acceptWithResult(IteratorBlock.java:108)
	at freemarker.core.IteratorBlock.accept(IteratorBlock.java:94)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.springframework.web.servlet.view.tiles3.TilesView.renderMergedOutputModel(TilesView.java:132)
	at pl.edu.icm.synat.common.ui.tiles.FreeMarkerAndTilesView.renderMergedOutputModel(FreeMarkerAndTilesView.java:148)
	at org.springframework.web.servlet.view.AbstractView.render(AbstractView.java:303)
	at org.springframework.web.servlet.DispatcherServlet.render(DispatcherServlet.java:1243)
	at org.springframework.web.servlet.DispatcherServlet.processDispatchResult(DispatcherServlet.java:1027)
	at org.springframework.web.servlet.DispatcherServlet.doDispatch(DispatcherServlet.java:971)
	at org.springframework.web.servlet.DispatcherServlet.doService(DispatcherServlet.java:893)
	at org.springframework.web.servlet.FrameworkServlet.processRequest(FrameworkServlet.java:965)
	at org.springframework.web.servlet.FrameworkServlet.doGet(FrameworkServlet.java:856)
	at javax.servlet.http.HttpServlet.service(HttpServlet.java:620)
	at org.springframework.web.servlet.FrameworkServlet.service(FrameworkServlet.java:841)
	at javax.servlet.http.HttpServlet.service(HttpServlet.java:727)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:303)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:316)
	at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.invoke(FilterSecurityInterceptor.java:126)
	at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.doFilter(FilterSecurityInterceptor.java:90)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.access.ExceptionTranslationFilter.doFilter(ExceptionTranslationFilter.java:114)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.session.SessionManagementFilter.doFilter(SessionManagementFilter.java:122)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AnonymousAuthenticationFilter.doFilter(AnonymousAuthenticationFilter.java:111)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.rememberme.RememberMeAuthenticationFilter.doFilter(RememberMeAuthenticationFilter.java:149)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.servletapi.SecurityContextHolderAwareRequestFilter.doFilter(SecurityContextHolderAwareRequestFilter.java:168)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.savedrequest.RequestCacheAwareFilter.doFilter(RequestCacheAwareFilter.java:48)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:207)
	at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:184)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.jasig.cas.client.session.SingleSignOutFilter.doFilter(SingleSignOutFilter.java:100)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.header.HeaderWriterFilter.doFilterInternal(HeaderWriterFilter.java:64)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.context.request.async.WebAsyncManagerIntegrationFilter.doFilterInternal(WebAsyncManagerIntegrationFilter.java:53)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.session.ConcurrentSessionFilter.doFilter(ConcurrentSessionFilter.java:133)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.context.SecurityContextPersistenceFilter.doFilter(SecurityContextPersistenceFilter.java:91)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.access.channel.ChannelProcessingFilter.doFilter(ChannelProcessingFilter.java:152)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.saml.metadata.MetadataGeneratorFilter.doFilter(MetadataGeneratorFilter.java:87)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at pl.edu.icm.synat.portal.web.security.PortalLocaleFilter.doFilterInternal(PortalLocaleFilter.java:51)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:213)
	at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:176)
	at org.springframework.web.filter.DelegatingFilterProxy.invokeDelegate(DelegatingFilterProxy.java:344)
	at org.springframework.web.filter.DelegatingFilterProxy.doFilter(DelegatingFilterProxy.java:261)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at ch.qos.logback.classic.helpers.MDCInsertingServletFilter.doFilter(MDCInsertingServletFilter.java:51)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.springframework.web.filter.CharacterEncodingFilter.doFilterInternal(CharacterEncodingFilter.java:85)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at pl.edu.icm.synat.portal.web.security.RemoteIpFilter.doFilter(RemoteIpFilter.java:75)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:219)
	at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:196)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:220)
	at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:122)
	at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:504)
	at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:170)
	at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:103)
	at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:116)
	at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:421)
	at org.apache.coyote.ajp.AjpProcessor.process(AjpProcessor.java:190)
	at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:611)
	at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:314)
	at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1142)
	at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:617)
	at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
	at java.lang.Thread.run(Thread.java:745)
Caused by: org.springframework.context.NoSuchMessageException: No message found under code 'portal.searchResult.facet.^journalYear^journalVolume' for locale 'en'.
	at org.springframework.context.support.AbstractMessageSource.getMessage(AbstractMessageSource.java:159)
	at org.springframework.context.support.DelegatingMessageSource.getMessage(DelegatingMessageSource.java:66)
	at org.springframework.context.support.AbstractApplicationContext.getMessage(AbstractApplicationContext.java:1129)
	at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:712)
	at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:678)
	at sun.reflect.GeneratedMethodAccessor237.invoke(Unknown Source)
	at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
	at java.lang.reflect.Method.invoke(Method.java:497)
	at freemarker.ext.beans.BeansWrapper.invokeMethod(BeansWrapper.java:1458)
	at freemarker.ext.beans.ReflectionCallableMemberDescriptor.invokeMethod(ReflectionCallableMemberDescriptor.java:56)
	at freemarker.ext.beans.MemberAndArguments.invokeMethod(MemberAndArguments.java:51)
	at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:61)
	... 179 more

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Cell Metabolism

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