Toxicology and Applied Pharmacology

Items from 1 to 20 out of 7,600 results

article

Changes in Gap Junction Permeability, Gap Junction Number, and Connexin43 Expression in Lindane-Treated Rat Liver Epithelial Cells

X.J. Guan, W.J. Bonney, R.J. Ruch

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 79-86

The pesticide lindane (γ-hexachlorocyclohexane) is a mammalian neurotoxin and hepatocarcinogen. Lindane can inhibit gap junctional intercellular communication (GJIC) and this effect may contribute to its toxic properties. The mechanism of inhibition of GJIC by lindane in WB-F344 rat liver epithelial cells was studied to determine if altered gap junction permeability, gap junction number, and/or gap...

article

Renal Tumorigenicity of 1,1-Dichloroethene in Mice: The Role of Male-Specific Expression of Cytochrome P450 2E1 in the Renal Bioactivation of 1,1-Dichloroethene

P. Speerschneider, W. Dekant

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 48-56

1,1-Dichloroethene is used as intermediate in the manufacture of polymers. In male mice, 1,1-dichloroethene caused renal tumors after inhalation. Renal tumors were not observed in female mice or in both sexes of rats. We investigated the metabolic basis for the species- and sex-specific nephrotoxicity and tumorigenicity of 1,1-dichloroethene. Kidney microsomes from male mice biotransformed 1,1-dichloroethene...

article

Increased ( ³ H) Phorbol Ester Binding in Rat Cerebellar Granule Cells by Polychlorinated Biphenyl Mixtures and Congeners: Structure-Activity Relationships

P.R.S. Kodavanti, T.R. Ward, J.D. Mckinney, H.A. Tilson

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 140-148

Our previous reports indicate that polychlorinated biphenyl (PCB) congeners in vitro perturbed cellular Ca ² ⁺ homeostasis and protein kinase C (PKC) translocation. We have now studied the structure-activity relationship (SAR) of 3 PCB mixtures, 24 PCB congeners, and 1 dibenzofuran for their effects on PKC translocation by measuring [ ³ H]phorbol ester ([ ³ H]PDBu) binding...

article

Methoxychlor Regulates Rat Uterine Estrogen-Induced Protein

A.M. Cummings, J.L. Metcalf

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 154-160

Methoxychlor (MXC), a proestrogenic pesticide, has adverse effects on fertility and uterine function in rodents. MXC is converted to an estrogenic substance, 2,2-bis-(p-hydroxyphenyl)1,1,1 -trichloroethane (HPTE), which binds to the estrogen receptor. We examined the similarities in mechanism between MXC (500 mg/kg) and estrogen (10 μg/rat) actions using the estrogen-induced protein, IP, also known...

article

Xenobiotic Metabolizing Enzyme Activities and Viability Are Well Preserved in EDTA-Isolated Rat Liver Parenchymal Cells after Cryopreservation

B. Diener, H. Abdellatif, M. Arand, F. Oesch

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 149-153

Rat liver parenchymal cells (PC) were isolated by EDTA perfusion and were purified by a subsequent Percoll centrifugation. The isolated PC had a viability of 95%, as judged by trypan blue exclusion. Freshly isolated PC were cryopreserved with an optimized protocol in a computer-controlled freezer. After thawing, the PC still retained a viability of 89%. The activities of representative xenobiotic...

article

Characterization of Benzo[a]pyrene Quinone-Induced Toxicity to Primary Cultured Bone Marrow Stromal Cells from DBA/2 Mice: Potential Role of Mitochondrial Dysfunction

H. Zhu, Y.B. Li, M.A. Trush

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 108-120

Oral exposure of DBA/2 mice to benzo[a]pyrene (BP) has been shown to result in hematotoxicity which is manifested as aplastic anemia and leukemia. Since normal hematopoiesis is regulated by bone marrow stromal cells, in this study we have characterized the bone marrow stromal toxicity induced by BP and BP-derived metabolites, particularly quinones. Incubation of stromal cells with various concentrations...

article

Cumulative Labeling Indexes in Epithelial Cell Populations of the Respiratory Tract After Exposure to Ozone at Low Concentrations

P. Rajini, H. Witschi

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 32-40

Male Sprague-Dawley and F344 rats were exposed to concentrations of 0.12 ppm of ozone for 12 hr a night or for 24 hr a day, to 0.24 ppm for 24 hr a day, and to 0.36 ppm for 8 hr a night. Cumulative labeling indices were measured during the first and the third week of exposure in the terminal bronchioles, the large intrapulmonary airways, the trachea, and the anterior nasal passages. The most sensitive...

article

Early Changes in Sex Hormones Are Not Evident in Mice Exposed to the Uterine Carcinogens Chloroethane or Bromoethane

J.R. Bucher, D.L. Morgan, B. Adkins, G.S. Travlos, more

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 169-173

Chloroethane and bromoethane have been shown to cause a marked uterine tumor response in B6C3F ₁ mice exposed for 2 years. These chemicals are nearly unique in this regard among the nearly 400 chemicals studied by the National Toxicology Program, and the reasons for this carcinogenic activity are unclear. The possible relationship of changes in blood concentrations of sex hormones to this...

article

Single Versus Multiple Dose Administration of All-trans-retinoic Acid during Organogenesis: Differential Metabolism and Transplacental Kinetics in Rat and Rabbit

M.D. Collins, G. Tzimas, H. Burgin, H. Hummler, more

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 9-18

Standard teratogenicity testing is usually performed by administration of a test compound daily throughout an extended period of organogenesis (e.g., between Days 6 and 15 in rat and 6 and 18 in rabbit). On the other hand, single dose experiments during a specific period were often demonstrated to be more effective in unveiling a particular teratogenic effect. We have assessed here if toxicokinetics...

article

Relationship Between Glutathione Concentration and Metabolism of the Pyrrolizidine Alkaloid, Monocrotaline, in the Isolated, Perfused Liver

C.C. Yan, R.J. Huxtable

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 132-139

The influence of GSH concentration on metabolism of monocrotaline was examined in the isolated, perfused rat liver. Chloroethanol (0.37 mmol/kg), diethyl maleate (5.6 mmol/kg), and buthionine sulfoximine (72.9 mmol/kg) given in vivo reduced hepatic GSH from 3.7 μmol/g wet weight to 1.5, 0.6 and 0.9 μmol/g, respectively. Livers were then perfused in vitro for 1 hr with monocrotaline (0.5 mM). GSH depletion...

article

Progressive Losses of Renal Mass and the Renal and Hepatic Disposition of Administered Inorganic Mercury

R.K. Zalups

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 121-131

The present study was designed to evaluate, in rats, the effect of progressive losses of renal mass, from a state where renal function is not compromised significantly to a state where the early stages of renal failure are detectable, on the disposition of administered inorganic mercury. As part of this evaluation, the intrarenal, hepatic, and hematological disposition of mercury and the urinary and...

article

Toxicity of Mitomycin C Toward Cultured Pulmonary Artery Endothelium

C.M. Hoorn, J.G. Wagner, T.W. Petry, R.A. Roth

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 87-94

Mitomycin C (MMC) is a bifunctional alkylating agent used in cancer chemotherapy. MMC therapy occasionally results in pulmonary vascular injury, including alterations in endothelial cells. Reactive metabolites of MMC can cross-link DNA, and its cytotoxicity has been attributed in part to this capacity, but effects in vascular cells have not been explored extensively. Accordingly, the direct effects...

article

The Relationship Between the Concentration of the Pyrrolizidine Alkaloid Monocrotaline and the Pattern of Metabolites Released from the Isolated Liver

C.C. Yan, R.J. Huxtable

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 1-8

Hepatic metabolism of the pyrrolizidine alkaloid monocrotaline results in extrahepatic toxicity caused by the release of metabolites from the liver. We have quantified the release of pyrrolic metabolites into the perfusate and bile of isolated rat livers perfused with monocrotaline over the concentration range of 0.125-1.5 mM. Over a 1-hr perfusion period, the amount of dehydromonocrotaline released...

article

Effect of Cisplatin on Renal-Function in Rabbits: Mechanism of Reduced Glucose Reabsorption

Y.K. Kim, H.S. Byun, Y.H. Kim, J.S. Woo, more

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 19-26

This study was performed to determine the effect of cisplatin (cis-diamminedichloroplatinum II) on renal function in rabbits. Injection of a single i.p. dose of 4 mg/kg cisplatin caused an increase in fractional excretion of Na ⁺ and K ⁺ and a decrease in urine osmolality (U _o _s _m ), free-water reabsorption, (T ^c H ₂ O), and urine to plasma creatinine...

article

Discrepancy between the Nephrotoxic Potencies of Cadmium-Metallothionein and Cadmium Chloride and the Renal Concentration of Cadmium in the Proximal Convoluted Tubules

C. Dorian, V.H. Gattone, C.D. Klaassen

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 161-168

Acute exposure to inorganic cadmium produces hepatotoxicity, but no renal injury. In contrast, chronic exposure to Cd produces nephrotoxic effects. However, a single injection of cadmium bound to metallothionein (CdMT) can produce nephrotoxicity similar to that seen with chronic exposure to Cd. It is generally thought that CdMT is nephrotoxic because more CdMT than CdCl ₂ distributes to the...

article

Iron(II) Is a Modulator of Ryanodine-Sensitive Calcium Channels of Cardiac Muscle Sarcoplasmic Reticulum

E. Kim, S.N. Giri, I.N. Pessah

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 57-66

Iron is examined for its ability to modify Ca ² ⁺ transport across sarcoplasmic reticulum (SR) and to alter the binding of [ ³ H]ryanodine to its high-affinity site on the Ca ² ⁺ release channel complex of SR preparations from rat heart. Iron(III) (added as ferric chloride) has negligible activity on active Ca ² ⁺ accumulation into SR and on the binding...

article

Cantharidin Effects on Protein Phosphatases and the Phosphorylation State of Phosphoproteins in Mice

R. Eldridge, J.E. Casida

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 95-100

Our earlier studies indicated that the action of cantharidin (CA) in mice is associated with binding to protein phosphatase 2A in liver cytosol and inhibition of its phosphorylase a phosphatase activity. In this investigation, we find that CA totally inhibits the phosphorylase a phosphatase activity in mouse liver, muscle, and skin cytosol at 5000 nM, with IC50s of 110-250 nM. About 50% of the phosphorylase...

article

Muller Cell Involvement in Methanol-Induced Retinal Toxicity

C.D. Garner, E.W. Lee, R.T. Louisferdinand

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 101-107

Methanol is an ocular toxicant which causes visual dysfunction often leading to blindness after acute exposure. The physiological and biochemical changes responsible for this toxicity are poorly understood. Previously, we reported that the folate-reduced (FR) rat is an animal model which mimics the characteristic human methanol toxicities. The present study examines the hypothesis that depletion of...

article

Behavioral Evaluation of the Irritant Properties of Formaldehyde

R.W. Wood, J.B. Coleman

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 67-72

The effects of formaldehyde were determined using a behavioral technique that permits the estimation of the aversiveness of airborne chemical irritants. Eight mice were initially trained to terminate presentations of ammonia by poking their nose into a conical sensor; five pokes terminated the presentation and produced a facial shower of clean air. Ammonia (1000 ppm) or formaldehyde (1.0-10 ppm) was...

article

Antimony-Induced Oxidative Stress and Toxicity in Cultured Cardiac Myocytes

M.A. Tirmenstein, P.I. Plews, C.V. Walker, M.D. Woolery, more

Toxicology and Applied Pharmacology > 1995 > 130 > 1 > 41-47

Cardiac myocytes were exposed to concentrations of potassium antimonyl tartrate (PAT) ranging from 1 to 1000 μM for 1 to 24 hr. Toxicity was assessed by measuring lactate dehydrogenase (LDH) release and by monitoring chronotropic depression. Lipid peroxidation was assessed by measuring the release of thiobarbituric acid reactive substances (TBARS). PAT produced a concentration- and time-dependent...

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Java method "org.springframework.web.servlet.support.RequestContext.getMessage(String)" threw an exception when invoked on org.springframework.web.servlet.support.RequestContext object "org.springframework.web.servlet.support.RequestContext@242c851a"; see cause exception in the Java stack trace.

----
FTL stack trace ("~" means nesting-related):
	- Failed at: ${springMacroRequestContext.getMessag...  [in template "META-INF/freemarker-templates/spring.ftl" in macro "message" at line 28, column 22]
	- Reached through: @spring.message "portal.searchResult...  [in template "META-INF/freemarker-templates/portal/search/facets.ftl" at line 149, column 33]
----

Java stack trace (for programmers):
----
freemarker.core._TemplateModelException: [... Exception message was already printed; see it above ...]
	at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:289)
	at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:261)
	at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:65)
	at freemarker.core.MethodCall._eval(MethodCall.java:65)
	at freemarker.core.Expression.eval(Expression.java:81)
	at freemarker.core.DollarVariable.calculateInterpolatedStringOrMarkup(DollarVariable.java:96)
	at freemarker.core.DollarVariable.accept(DollarVariable.java:59)
	at freemarker.core.Environment.visit(Environment.java:363)
	at freemarker.core.Environment.invoke(Environment.java:715)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:369)
	at freemarker.core.IteratorBlock$IterationContext.executedNestedContentForCollOrSeqListing(IteratorBlock.java:316)
	at freemarker.core.IteratorBlock$IterationContext.executeNestedContent(IteratorBlock.java:272)
	at freemarker.core.IteratorBlock$IterationContext.accept(IteratorBlock.java:243)
	at freemarker.core.Environment.visitIteratorBlock(Environment.java:596)
	at freemarker.core.IteratorBlock.acceptWithResult(IteratorBlock.java:108)
	at freemarker.core.IteratorBlock.accept(IteratorBlock.java:94)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.springframework.web.servlet.view.tiles3.TilesView.renderMergedOutputModel(TilesView.java:132)
	at pl.edu.icm.synat.common.ui.tiles.FreeMarkerAndTilesView.renderMergedOutputModel(FreeMarkerAndTilesView.java:148)
	at org.springframework.web.servlet.view.AbstractView.render(AbstractView.java:303)
	at org.springframework.web.servlet.DispatcherServlet.render(DispatcherServlet.java:1243)
	at org.springframework.web.servlet.DispatcherServlet.processDispatchResult(DispatcherServlet.java:1027)
	at org.springframework.web.servlet.DispatcherServlet.doDispatch(DispatcherServlet.java:971)
	at org.springframework.web.servlet.DispatcherServlet.doService(DispatcherServlet.java:893)
	at org.springframework.web.servlet.FrameworkServlet.processRequest(FrameworkServlet.java:965)
	at org.springframework.web.servlet.FrameworkServlet.doGet(FrameworkServlet.java:856)
	at javax.servlet.http.HttpServlet.service(HttpServlet.java:620)
	at org.springframework.web.servlet.FrameworkServlet.service(FrameworkServlet.java:841)
	at javax.servlet.http.HttpServlet.service(HttpServlet.java:727)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:303)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:316)
	at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.invoke(FilterSecurityInterceptor.java:126)
	at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.doFilter(FilterSecurityInterceptor.java:90)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.access.ExceptionTranslationFilter.doFilter(ExceptionTranslationFilter.java:114)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.session.SessionManagementFilter.doFilter(SessionManagementFilter.java:122)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AnonymousAuthenticationFilter.doFilter(AnonymousAuthenticationFilter.java:111)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.rememberme.RememberMeAuthenticationFilter.doFilter(RememberMeAuthenticationFilter.java:149)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.servletapi.SecurityContextHolderAwareRequestFilter.doFilter(SecurityContextHolderAwareRequestFilter.java:168)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.savedrequest.RequestCacheAwareFilter.doFilter(RequestCacheAwareFilter.java:48)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:207)
	at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:184)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.jasig.cas.client.session.SingleSignOutFilter.doFilter(SingleSignOutFilter.java:100)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.header.HeaderWriterFilter.doFilterInternal(HeaderWriterFilter.java:64)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.context.request.async.WebAsyncManagerIntegrationFilter.doFilterInternal(WebAsyncManagerIntegrationFilter.java:53)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.session.ConcurrentSessionFilter.doFilter(ConcurrentSessionFilter.java:133)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.context.SecurityContextPersistenceFilter.doFilter(SecurityContextPersistenceFilter.java:91)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.access.channel.ChannelProcessingFilter.doFilter(ChannelProcessingFilter.java:152)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.saml.metadata.MetadataGeneratorFilter.doFilter(MetadataGeneratorFilter.java:87)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at pl.edu.icm.synat.portal.web.security.PortalLocaleFilter.doFilterInternal(PortalLocaleFilter.java:51)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:213)
	at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:176)
	at org.springframework.web.filter.DelegatingFilterProxy.invokeDelegate(DelegatingFilterProxy.java:344)
	at org.springframework.web.filter.DelegatingFilterProxy.doFilter(DelegatingFilterProxy.java:261)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at ch.qos.logback.classic.helpers.MDCInsertingServletFilter.doFilter(MDCInsertingServletFilter.java:51)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.springframework.web.filter.CharacterEncodingFilter.doFilterInternal(CharacterEncodingFilter.java:85)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at pl.edu.icm.synat.portal.web.security.RemoteIpFilter.doFilter(RemoteIpFilter.java:75)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:219)
	at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:196)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:220)
	at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:122)
	at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:504)
	at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:170)
	at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:103)
	at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:116)
	at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:421)
	at org.apache.coyote.ajp.AjpProcessor.process(AjpProcessor.java:190)
	at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:611)
	at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:314)
	at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1142)
	at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:617)
	at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
	at java.lang.Thread.run(Thread.java:745)
Caused by: org.springframework.context.NoSuchMessageException: No message found under code 'portal.searchResult.facet.^journalYear^journalVolume^journalNumber' for locale 'en'.
	at org.springframework.context.support.AbstractMessageSource.getMessage(AbstractMessageSource.java:159)
	at org.springframework.context.support.DelegatingMessageSource.getMessage(DelegatingMessageSource.java:66)
	at org.springframework.context.support.AbstractApplicationContext.getMessage(AbstractApplicationContext.java:1129)
	at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:712)
	at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:678)
	at sun.reflect.GeneratedMethodAccessor237.invoke(Unknown Source)
	at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
	at java.lang.reflect.Method.invoke(Method.java:497)
	at freemarker.ext.beans.BeansWrapper.invokeMethod(BeansWrapper.java:1458)
	at freemarker.ext.beans.ReflectionCallableMemberDescriptor.invokeMethod(ReflectionCallableMemberDescriptor.java:56)
	at freemarker.ext.beans.MemberAndArguments.invokeMethod(MemberAndArguments.java:51)
	at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:61)
	... 179 more

Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program: SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.

INFONA - science communication portal

Toxicology and Applied Pharmacology

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