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To evaluate the presence of spermatogonia in men diagnosed with Klinefelter syndrome (KS), in whom no testicular spermatozoa were recovered by testicular sperm extraction.Retrospective case series.University hospital.Testicular samples from 22 nonmosaic 47,XXY men, aged 24–43 years, with no spermatozoa at multiple biopsies.Paraffin-embedded testicular tissue was sectioned and stained with hematoxylin-eosin,...
Klinefelter syndrome is the most prevalent chromosome abnormality and genetic cause of azoospermia in males. The availability of assisted reproductive technology (ART) has allowed men with Klinefelter syndrome to father their own genetic offspring. When providing ART to men with Klinefelter syndrome, it is important to be able to counsel them properly on both the chance of finding sperm and the potential...
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