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Application of fluorescence imaging of cardiac electrical activity is limited by motion artifacts and/or side effects of currently available pharmacologic excitation–contraction uncoupling agents.The purpose of this study was to test whether blebbistatin, a recently discovered inhibitor of myosin II isoforms, can be used as an excitation–contraction uncoupler.The specificity and potency of blebbistatin...
Fish oil reduces the incidence of sudden cardiac death in postmyocardial infarction patients. Triggered activity is the principal mechanism of arrhythmogenesis under these conditions.The purpose of this study was to test whether dietary fish oil in pigs inhibits Ca 2+ overload-induced triggered activity.Pigs were fed a diet of fish oil or sunflower oil for 8 weeks. Ventricular myocytes (ω3:...
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