Clinical Biochemistry

Items from 1 to 20 out of 7,180 results

article

Elevation of Activity of Creatine Phosphokinase (CK) and Its Isoenzymes in the Newborn Is Associated With Fetal Asphyxia and Risk at Birth

Eugenia Fonseca, Angel Garcia-Alonso, Arturo Zárate, Raquel Ochoa, more

Clinical Biochemistry > 1995 > 28 > 1 > 91-95

Objective: To investigate the relationship of creatine phosphokinase and its isoenzymes with fetal asphyxia and risk at birth.Methods: Thirty-five pregnant women with high-risk pregnancy were studied.Results: In 21 patients, fetal distress was diagnosed by interpretation of the fetal heart rate tracing (FHR). The remaining 14 women, having normal fetal cardiotocography, were considered as the control...

article

Assessment of the Antielastase Activities in Bronchoalveolar Lavage Fluid: Effect of Assay Buffer Ionic Strength

A. Felix Ofulue, Raja T. Abboud

Clinical Biochemistry > 1995 > 28 > 1 > 63-69

Objective: To evaluate the effect of assay buffer ionic strength on assessment of the antielastase activities in bronchoalveolar lavage fluid.Method: An improved assay protocol in which elastase (in Tris-HCI buffer) is added to increasing volumes of test samples (made up to equal volume with phosphate-buffered saline) was used.Results: The percent NE activity inhibited by BALF decreased with increasing...

article

Specific Heparin Preparations Interfere With the Simultaneous Measurement of Ionized Magnesium and Ionized Calcium

Martha E. Lyon, Debbie Bremner, Thomas Laha, Sohail Malik, more

Clinical Biochemistry > 1995 > 28 > 1 > 79-84

Objective: To determine whether heparin anticoagulants used for analysis of whole blood ionized calcium would influence the measurement of ionized magnesium.Methods: The effects of zinc heparin, lithium heparin, and electrolyte-balanced heparin on the simultaneous measurement of ionized magnesium and ionized calcium in serum were determined using ion selective electrodes.Results: Time-dependent biases...

article

Prolonged Survival in Pyruvate Carboxylase Deficiency: Lack of Correlation With Enzyme Activity in Cultured Fibroblasts

Harvey J. Stern, Ritu Nayar, Louis Depalma, Nader Rifai

Clinical Biochemistry > 1995 > 28 > 1 > 85-89

Objective: To report the clinical history and laboratory evaluation of a patient presenting with lactic acidosis secondary to pyruvate carboxylase deficiency.Methods and Results: Enzyme analysis of cultured skin fibroblasts revealed 2-5% of normal pyruvate carboxylase activity. Although most patients with this condition die in early infancy, this child has survived to age 8-1/2 years, with only occasional...

article

An Epidemiological Perspective on Cancer Screening

Anthony B. Miller

Clinical Biochemistry > 1995 > 28 > 1 > 41-48

Objective: To provide an epidemiological perspective on cancer screening.Methods and Results: For screening to be applicable as public health policy, the disease has to be an important health problem, there has to be evidence that early detection results in improved outcome, that adequate facilities for diagnosis, therapy, and subsequent management of true and false positives are available, that screening...

article

Biochemical Markers of Myocardial Damage

V. Bhayana, A. Ralph Henderson

Clinical Biochemistry > 1995 > 28 > 1 > 1-29

Objective: To assess various biochemical markers of myocardial damage.Methods and Results: Before routinely using any test as a biochemical marker of myocardial damage, the published evidence for its diagnostic utility must be critically assessed. Such assessment includes receiver operator curve (ROC) curve analyses, confidence interval estimates of claimed sensitivity and specificity values, and...

article

Type 1-Prophospholipase A ₂ Propeptide Immunoreactivity Is Released From Activated Granulocytes

David Rae, Nazira Sumar, Nicolas Beechey-Newman, Mark Gudgeon, more

Clinical Biochemistry > 1995 > 28 > 1 > 71-78

Objective: To establish a ELISA assay to measure release of type 1-phospholipase A ₂ propeptide from activated granulocytes. Human type 1-prophospholipase A ₂ (1-proPLA ₂ ) is biosynthesized and stored as inactive zymogen. Activation involves tryptic-like cleavage at the N-terminus, with equimolar release of the heptapeptide DSGISPR.Methods: Using antibodies directed to the...

article

Lipid and Lipoprotein Genetic Variability: An Important Contribution From the French Health Examination Centers

G. Siest, J. Henny, M.M. Galteau, F. Schiele, more

Clinical Biochemistry > 1995 > 28 > 1 > 31-38

Objective: To assess lipid and lipoprotein genetic variability in the French Population.Methods: Many health examination centers are covering a great part of France (700,000 individuals are examined in 54 centers every year). Each citizen has the right to have a personal examination every 5 years. This unique system was modified in 1992, and we are presenting our 25-year experience focusing on the...

article

Fluorescence-Activated Cytometry Cell Sorting Based on Immunological Recognition

Mario Assenmacher, Rudi Manz, Stefan Miltenyi, Alexander Scheffold, more

Clinical Biochemistry > 1995 > 28 > 1 > 39-40

article

Evaluation of an Immunoturbidimetric Assay for Hemoglobin A ₁ _C

Andrew W. Lyon, Bernard Schaan, Victor A. Laxdal, K. Lorne Massey

Clinical Biochemistry > 1995 > 28 > 1 > 97-100

article

Interference in Triiodothyronine (T ₃ ) Analysis on the Immuno 1 Analyzer

Tao Wang, Betty S.-Y. Wan, Sinikka K. Makela, Graham Ellis

Clinical Biochemistry > 1995 > 28 > 1 > 55-62

Objective: To evaluate the interference in Triiodothyronine (T ₃ ) analysis on the Immuno 1 Analyzer.Methods: We analyzed 686 samples for T ₃ using the Miles Technicon Immuno 1 Analyzer. We compared the results of 318 samples with those given by radioimmunoassay (RIA) and the remaining 368 results with those given by the Ciba-Corning ACS 180 analyzer.Results: On the Immuno 1 correlated...

article

Urinary 6β-Hydroxycortisol in Humans: Analysis, Biological Variations, and Reference Ranges

Chul Lee

Clinical Biochemistry > 1995 > 28 > 1 > 49-54

Objective: To evaluate methods for analysis, biological variation, and reference ranges for 6β-hydroxycortisol in urine.Methods: The urinary level of 6β-hydroxycortisol (6β-OHF) was measured by reversed-phase high performance liquid chromatography.Results: The method was accurate and precise, as indicated by a recovery rate of 92-95% and less than 5.5% and 6.6% of coefficient of variation for within-run...

article

Whatever Happened to PKU?

Charles R. Scriver

Clinical Biochemistry > 1995 > 28 > 2 > 137-144

The history of PKU is one of science in the discovery of an inborn error of metabolism and a chemical cause of mental retardation; and also one of technology with the development of methods to prevent disease. PKU is the classic example of success in the prevention of a genetic disease. Meanwhile, the science has continued to evolve over the 60 years since the discovery of PKU, generating new understanding...

article

Evaluation of the i-STAT ^T ^M System: A Portable Chemistry Analyzer for the Measurement of Sodium, Potassium, Chloride, Urea, Glucose, and Hematocrit

Thomas Mock, Douglas Morrison, Randall Yatscoff

Clinical Biochemistry > 1995 > 28 > 2 > 187-192

Objective: To evaluate the analytical performance of the i-STAT ^T ^M system, which is designed for point of care testing and employs a hand-held chemistry analyzer and disposable cartridges, which in the configuration tested, are capable of measuring sodium, potassium, chloride, urea, glucose, and hematocrit in approximately 65 μL of blood in 90 s.Methods: Linearity and imprecision in hematocrit...

article

Human Bioassays to Assess Environmental Genotoxicity: Development of a DNA Break Bioassay in HepG2 Cells

Bruce M. Hasspieler, Furat N. Ali, Masumeh Alipour, G. Douglas Haffner, more

Clinical Biochemistry > 1995 > 28 > 2 > 113-116

Objectives: Increasing interest in environmental health issues has created a demand for improved methods for the assessment of pollutant effects on humans. Our laboratory has developed anin vitro assay for the quantification of genotoxicity, monitored as DNA single strand breaks (SSB), in the HepG2 human hepatoma cell line.Design and Methods: This assay procedure, which is based upon alkaline unwinding...

article

Correlation Between Plasma Malondialdehyde and Ceruloplasmin Activity Values in Rheumatoid Arthritis

Hilâl Özgüneş, Hande Gürer, Safiye Tuncer

Clinical Biochemistry > 1995 > 28 > 2 > 193-194

article

In Honor of Dr. Roger Thibert's Retirement

R. Yatscoff, K. Adeli

Clinical Biochemistry > 1995 > 28 > 2 > V

article

A Protease Assay Using Time-Resolved Lanthanide Luminescence From an Engineered Calcium Binding Protein Substrate

Ian D. Clark, John P. Macmanus, Arthur G. Szabo

Clinical Biochemistry > 1995 > 28 > 2 > 131-135

Objectives: The objective of this work was to demonstrate the utility of luminescence from lanthanides bound to a mutant of the Ca ² ⁺ binding protein, oncomodulin, to monitor protease activity.Design and Methods: A mutant of oncomodulin with a cysteine residue at position 57 located in the CD binding loop was conjugated to a salicylic acid group. The luminescence of Tb ³ ⁺ ...

article

β-Hexosaminidase: Biosynthesis and Processing of the Normal Enzyme, and Identification of Mutations Causing Jewish Tay-Sachs Disease

Don J. Mahuran

Clinical Biochemistry > 1995 > 28 > 2 > 101-106

Objectives: This report presents an overview of the nearly 100-year history of the study of Tay-Sachs disease in the Ashkenazi Jewish population.Design and Methods: Each major step leading to our present understanding of the disease are highlighted.Results: The original interest in the cause of this devastating disease in the late 1800s led to the identification of a novel glycolipid, G _M ...

article

Relationship Between Red Blood Cell Antioxidant Enzymatic System Status and Lipoperoxidation During the Acute Phase of Malaria

M.C. Delmas-Beauvieux, E. Peuchant, M.F. Dumon, M.C. Receveur, more

Clinical Biochemistry > 1995 > 28 > 2 > 163-169

Objective: To investigate the relationship between oxidative stress and aggrevation of the disease in patients with malaria.Methods and Results: In the present study lipoperoxidation was demonstrated during the acute phase of malaria by a significant decrease in polyunsaturated fatty acids (PUFA). The lowest values of PUFA were obtained for C20:4 and C22:6, which were the main targets of reactive...

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FreeMarker template error (HTML_DEBUG mode; use RETHROW in production!)


Java method "org.springframework.web.servlet.support.RequestContext.getMessage(String)" threw an exception when invoked on org.springframework.web.servlet.support.RequestContext object "org.springframework.web.servlet.support.RequestContext@4387f4f7"; see cause exception in the Java stack trace.

----
FTL stack trace ("~" means nesting-related):
	- Failed at: ${springMacroRequestContext.getMessag...  [in template "META-INF/freemarker-templates/spring.ftl" in macro "message" at line 28, column 22]
	- Reached through: @spring.message "portal.searchResult...  [in template "META-INF/freemarker-templates/portal/search/facets.ftl" at line 149, column 33]
----

Java stack trace (for programmers):
----
freemarker.core._TemplateModelException: [... Exception message was already printed; see it above ...]
	at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:289)
	at freemarker.ext.beans._MethodUtil.newInvocationTemplateModelException(_MethodUtil.java:261)
	at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:65)
	at freemarker.core.MethodCall._eval(MethodCall.java:65)
	at freemarker.core.Expression.eval(Expression.java:81)
	at freemarker.core.DollarVariable.calculateInterpolatedStringOrMarkup(DollarVariable.java:96)
	at freemarker.core.DollarVariable.accept(DollarVariable.java:59)
	at freemarker.core.Environment.visit(Environment.java:363)
	at freemarker.core.Environment.invoke(Environment.java:715)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:369)
	at freemarker.core.IteratorBlock$IterationContext.executedNestedContentForCollOrSeqListing(IteratorBlock.java:316)
	at freemarker.core.IteratorBlock$IterationContext.executeNestedContent(IteratorBlock.java:272)
	at freemarker.core.IteratorBlock$IterationContext.accept(IteratorBlock.java:243)
	at freemarker.core.Environment.visitIteratorBlock(Environment.java:596)
	at freemarker.core.IteratorBlock.acceptWithResult(IteratorBlock.java:108)
	at freemarker.core.IteratorBlock.accept(IteratorBlock.java:94)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.template.InsertAttributeModel.renderAttribute(InsertAttributeModel.java:188)
	at org.apache.tiles.template.InsertAttributeModel.execute(InsertAttributeModel.java:132)
	at org.apache.tiles.jsp.taglib.InsertAttributeTag.doTag(InsertAttributeTag.java:299)
	at freemarker.ext.jsp.SimpleTagDirectiveModel.execute(SimpleTagDirectiveModel.java:92)
	at freemarker.core.Environment.visit(Environment.java:427)
	at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
	at freemarker.core.Environment.visit(Environment.java:327)
	at freemarker.core.Environment.visit(Environment.java:333)
	at freemarker.core.Environment.process(Environment.java:306)
	at freemarker.ext.servlet.FreemarkerServlet.processEnvironment(FreemarkerServlet.java:910)
	at freemarker.ext.servlet.FreemarkerServlet.process(FreemarkerServlet.java:879)
	at freemarker.ext.servlet.FreemarkerServlet.doGet(FreemarkerServlet.java:764)
	at org.apache.tiles.request.freemarker.render.FreemarkerRenderer.render(FreemarkerRenderer.java:73)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:259)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:397)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:238)
	at org.apache.tiles.impl.BasicTilesContainer.render(BasicTilesContainer.java:221)
	at org.apache.tiles.renderer.DefinitionRenderer.render(DefinitionRenderer.java:59)
	at org.springframework.web.servlet.view.tiles3.TilesView.renderMergedOutputModel(TilesView.java:132)
	at pl.edu.icm.synat.common.ui.tiles.FreeMarkerAndTilesView.renderMergedOutputModel(FreeMarkerAndTilesView.java:148)
	at org.springframework.web.servlet.view.AbstractView.render(AbstractView.java:303)
	at org.springframework.web.servlet.DispatcherServlet.render(DispatcherServlet.java:1243)
	at org.springframework.web.servlet.DispatcherServlet.processDispatchResult(DispatcherServlet.java:1027)
	at org.springframework.web.servlet.DispatcherServlet.doDispatch(DispatcherServlet.java:971)
	at org.springframework.web.servlet.DispatcherServlet.doService(DispatcherServlet.java:893)
	at org.springframework.web.servlet.FrameworkServlet.processRequest(FrameworkServlet.java:965)
	at org.springframework.web.servlet.FrameworkServlet.doGet(FrameworkServlet.java:856)
	at javax.servlet.http.HttpServlet.service(HttpServlet.java:620)
	at org.springframework.web.servlet.FrameworkServlet.service(FrameworkServlet.java:841)
	at javax.servlet.http.HttpServlet.service(HttpServlet.java:727)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:303)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:52)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:316)
	at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.invoke(FilterSecurityInterceptor.java:126)
	at org.springframework.security.web.access.intercept.FilterSecurityInterceptor.doFilter(FilterSecurityInterceptor.java:90)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.access.ExceptionTranslationFilter.doFilter(ExceptionTranslationFilter.java:114)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.session.SessionManagementFilter.doFilter(SessionManagementFilter.java:122)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AnonymousAuthenticationFilter.doFilter(AnonymousAuthenticationFilter.java:111)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.rememberme.RememberMeAuthenticationFilter.doFilter(RememberMeAuthenticationFilter.java:149)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.servletapi.SecurityContextHolderAwareRequestFilter.doFilter(SecurityContextHolderAwareRequestFilter.java:168)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.savedrequest.RequestCacheAwareFilter.doFilter(RequestCacheAwareFilter.java:48)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:207)
	at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:184)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.jasig.cas.client.session.SingleSignOutFilter.doFilter(SingleSignOutFilter.java:100)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.AbstractAuthenticationProcessingFilter.doFilter(AbstractAuthenticationProcessingFilter.java:205)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.authentication.logout.LogoutFilter.doFilter(LogoutFilter.java:120)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.header.HeaderWriterFilter.doFilterInternal(HeaderWriterFilter.java:64)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.context.request.async.WebAsyncManagerIntegrationFilter.doFilterInternal(WebAsyncManagerIntegrationFilter.java:53)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.session.ConcurrentSessionFilter.doFilter(ConcurrentSessionFilter.java:133)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.context.SecurityContextPersistenceFilter.doFilter(SecurityContextPersistenceFilter.java:91)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.access.channel.ChannelProcessingFilter.doFilter(ChannelProcessingFilter.java:152)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.saml.metadata.MetadataGeneratorFilter.doFilter(MetadataGeneratorFilter.java:87)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at pl.edu.icm.synat.portal.web.security.PortalLocaleFilter.doFilterInternal(PortalLocaleFilter.java:51)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.springframework.security.web.FilterChainProxy$VirtualFilterChain.doFilter(FilterChainProxy.java:330)
	at org.springframework.security.web.FilterChainProxy.doFilterInternal(FilterChainProxy.java:213)
	at org.springframework.security.web.FilterChainProxy.doFilter(FilterChainProxy.java:176)
	at org.springframework.web.filter.DelegatingFilterProxy.invokeDelegate(DelegatingFilterProxy.java:344)
	at org.springframework.web.filter.DelegatingFilterProxy.doFilter(DelegatingFilterProxy.java:261)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at ch.qos.logback.classic.helpers.MDCInsertingServletFilter.doFilter(MDCInsertingServletFilter.java:51)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.springframework.web.filter.CharacterEncodingFilter.doFilterInternal(CharacterEncodingFilter.java:85)
	at org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:107)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at pl.edu.icm.synat.portal.web.security.RemoteIpFilter.doFilter(RemoteIpFilter.java:75)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:219)
	at net.bull.javamelody.MonitoringFilter.doFilter(MonitoringFilter.java:196)
	at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:241)
	at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:208)
	at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:220)
	at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:122)
	at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:504)
	at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:170)
	at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:103)
	at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:116)
	at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:421)
	at org.apache.coyote.ajp.AjpProcessor.process(AjpProcessor.java:190)
	at org.apache.coyote.AbstractProtocol$AbstractConnectionHandler.process(AbstractProtocol.java:611)
	at org.apache.tomcat.util.net.JIoEndpoint$SocketProcessor.run(JIoEndpoint.java:314)
	at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1142)
	at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:617)
	at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61)
	at java.lang.Thread.run(Thread.java:745)
Caused by: org.springframework.context.NoSuchMessageException: No message found under code 'portal.searchResult.facet.^journalYear^journalVolume^journalNumber' for locale 'en'.
	at org.springframework.context.support.AbstractMessageSource.getMessage(AbstractMessageSource.java:159)
	at org.springframework.context.support.DelegatingMessageSource.getMessage(DelegatingMessageSource.java:66)
	at org.springframework.context.support.AbstractApplicationContext.getMessage(AbstractApplicationContext.java:1129)
	at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:712)
	at org.springframework.web.servlet.support.RequestContext.getMessage(RequestContext.java:678)
	at sun.reflect.GeneratedMethodAccessor237.invoke(Unknown Source)
	at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
	at java.lang.reflect.Method.invoke(Method.java:497)
	at freemarker.ext.beans.BeansWrapper.invokeMethod(BeansWrapper.java:1458)
	at freemarker.ext.beans.ReflectionCallableMemberDescriptor.invokeMethod(ReflectionCallableMemberDescriptor.java:56)
	at freemarker.ext.beans.MemberAndArguments.invokeMethod(MemberAndArguments.java:51)
	at freemarker.ext.beans.OverloadedMethodsModel.exec(OverloadedMethodsModel.java:61)
	... 179 more

Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program: SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.

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Clinical Biochemistry

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