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Because of the known CYP3A4 inhibition by calcium-channel blockers (CCBs), we hypothesized that there might be a drug-drug interaction between clopidogrel and dihydropyridines in patients with coronary artery disease.Clopidogrel is activated by CYP3A4, which also metabolizes CCBs of the dihydropyridine class.Responsiveness to clopidogrel was assessed by the vasodilator-stimulated phosphoprotein (VASP)...
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