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The innate immune mechanisms of the liver represent an important first line of defense against bacterial products, toxins, and food antigens coming from the intestine. Natural Killer (NK) and Natural Killer T cells (NKT) are components of the innate immune system with increased presence in the liver compared to other organs and have been reported to participate in the inflammatory processes during...
The integrin α E β 7 is believed to play a key role in retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. Five common single nucleotide polymorphisms spanning ITGAE, the gene encoding the α E (CD103) unit, were genotyped in 556 sarcoidosis patients and 465 controls. The −1088 A/G polymorphism was associated with sarcoidosis (P=0.004). An increased...
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