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We evaluated NK cell subsets and functions in previously immunodeficient HIV patients responding to ART. Cytokine receptor mRNA was quantitated in purified CD56 + cells. Data were correlated with CD4 + T-cell counts and IFNγ responses to CMV. NK cell IFNγ responses to K562 cells and proportions of CD56 lo NK cells were correlated in patients (p<0.001) and both were lower...
The mechanisms underlying the modulation of Natural Killer (NK) cell functions by intravenous immunoglobulin (IVIg) are poorly understood. Using an ex vivo whole blood assay system we demonstrate that IVIg suppresses NK cell cytotoxicity. This was paralleled by IVIg-induced degranulation of CD56 bright , CD16 positive NK cells, reduced expression of CD16 and elevated IFNγ release....
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