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We have previously described an analog peptide of type II collagen (CII) that can suppress collagen-induced arthritis (CIA). This analog peptide represents CII 245–270 , the immunodominant epitope of CII, but with substitutions at 260, 261, and 263 — CII 245–270 (A 260 , B 261 , and N 263 ) (A9). To elucidate the mechanisms responsible for suppression, we used...
The major risk factor for developing systemic lupus erythematosus (SLE) is being female. The present study utilized gene profiles of activated T cells from females with SLE and healthy controls to identify signaling pathways uniquely regulated by estradiol that could contribute to SLE pathogenesis. Selected downstream pathway genes (+/− estradiol) were measured by real time polymerase chain amplification...
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