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Matrix metalloproteinases (MMPs) modulate development, inflammation, and repair in lungs. Tissue inhibitors of MMPs (TIMPs) interact with MMPs, controlling the intensity and nature of the response to injury. Absence of MMP-9, -2, and -8 activities is associated with altered lung inflammation during allergic sensitization. To test the hypothesis that the absence of TIMP-1 enhances allergic lung inflammation,...
Matrix metalloproteinases (MMPs) play a vital role in the pathogenesis of several inflammatory diseases including tuberculosis through tissue remodeling. 1, 25(OH) 2 D 3 has several well recognized biological functions including suppression of MMP production. The influence of 1, 25(OH) 2 D 3 on MMP-7, MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), production...
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