Three new neo-clerodane diterpenoids, 6α-acetoxy-4α,18-epoxy-2α-hydroxy-13-neocleroden-15,16-olide (2α-hydroxyajugarin V), 4α,18-epoxy-2α,6α-dihydroxy-13-neocleroden-15,16-olide (2α-hydroxy-deacetylajugarin V) and 2α,6α-dihydroxy-4(18),13-neoclerodadien-15,16-olide (scutedrummonin), have been isolated from the aerial parts of Scutellaria drummondii, in addition to the known flavone xanthomicrol. The structures of the new diterpenoids were established by chemical and spectroscopic means, including X-ray diffraction analysis for 2α-hydroxyajugarin V.