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The efficacy, safety, and impact on quality of life of once daily treatment with simvastatin 20 mg and pravastatin 40 mg were compared in a multinational, randomized, double-blind trial involving 387 patients with primary mild to moderate hypercholesterolemia. The trial consisted of a 12-week baseline period, during the last 6 weeks of which patients received single-blind placebo, and a 12-week double-blind...
Patients with homozygous familial hypercholesterolaemia (HFH) have abnormalities in both low-density lipoprotein (LDL) receptor alleles, resulting in severe hypercholesterolaemia and premature coronary heart disease. Limited treatment options are available and the response to drug therapy has been poor. In the present paper, we have evaluated the efficacy and safety of simvastatin at doses beyond...
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