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Few data are available on the effects of high dose statin therapy on lipoprotein subfractions in type 2 diabetes. In a double blind randomised placebo-controlled trial we have studied the effects of 80mg atorvastatin over 8 weeks on LDL, VLDL and HDL subfractions in 40 overweight type 2 diabetes patients. VLDL and LDL subfractions were prepared by density gradient ultracentrifugation. Triglycerides,...
Proprotein convertase subtilisin kexin/type 9 (PCSK9) is an inhibitor of the low density (LDL) lipoprotein receptor. Plasma PCSK9 is increased by Fenofibrate and statins. Here, we determined how standard dose of statin and combined therapy with Fenofibrate modulate PCSK9.Randomized, open-label cross-over study investigating the effect of Fenofibrate (160mg), Atorvastatin (10mg), and combination of...
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