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The Hypertension High Risk Management trial (HYRIM) investigated the effect of fluvastatin treatment and lifestyle intervention on development of carotid intima–media thickness (IMT) in drug-treated hypertensive patients.HYRIM was a placebo-controlled, 2×2 factorial trial in which 568 drug-treated hypertensive men aged 40–74 years with total cholesterol 4.5–8.0mmol/L, triglycerides <4.5mmol/L,...
To explore synergistic effect between angiotensin II receptor blockers (ARBs) and statins on Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis.This study was a 2×2 factorial randomized, prospective, double-blind, placebo-controlled trial. One hundred and fifty nine hypertensive patients with carotid atherosclerosis were randomized to the administration of control...
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