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To be attributed with pleiotropism, statins need to show effects that are unrelated to plasma lipid lowering. In the studies of Nakamura et al. using fluvastatin, it is not clear that this was unequivocally the case. Furthermore, the observed effects of fluvastatin treatment on plaque stability may have been distorted by a potential effect of the drug on fibrinolysis. We conclude that more studies...
Several studies in experimental animals have shown that statins stabilize atheromatous plaques by increasing fibrous-cap thickness. However, direct evidence linking the use of statins to the incidence of plaque rupture in humans is lacking. We investigated whether statin treatment before the onset of ST-elevation myocardial infarction (STEMI) influences the incidence of plaque rupture detected by...
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