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Oxidative damage produced by reactive oxygen species (ROS) has been implicated in the etiology and pathology of many health conditions, including a large number of chronic diseases. Urinary biomarkers of oxidative status present a great opportunity to study redox balance in human populations. With urinary biomarkers, specimen collection is non-invasive and the organic/metal content is low, which minimizes...
8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), also known as 8-hydroxy-2′-deoxyguanosine (8-OHdG), is an oxidatively damaged nucleobases of DNA and is excreted into urine. Therefore, its urinary level is used as a sensitive marker for oxidative stress (OS). Although it can be measured by enzyme-linked immunosorbent assay (ELISA), its application to clinical pediatrics remains limited. Recently, a novel...
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