Biodiversity has become an internationally central concern. As such, it is crucial to fully consider it into social economy development. This paper explores how to carry out the biodiversity impact assessment (BIA) as a useful tool for biodiversity conservation. Taking Beibu Gulf economic zone as the case, the study predicts the impact of the industrial development plans for the period 2007-2020. The results indicate that: the impact of forest-pulp is stronger than the others, which is mainly on the understory-ecosystem diversity because of the Allelopathy of Eucalypts and successive planting. The results of this study also show that the indirect effects of the forest-pulp paper making, petrochemical industry and biomass energy on biodiversity are greater than their direct effect while the infrastructure construction are just the reverse. These impacts are huge and complicated, it is necessary to optimize and adjust the development plans on their scale and layout. On the other hand ecological zoning is a useful and important tool for zoning the prohibited and restricted development units for biodiversity conservation.