Capacitive micromachined ultrasonic transducers (CMUTs) are prone to having low transmit sensitivity. According to large signal CMUT models, this shortcoming can be overcome with higher pulse voltages and optimized bipolar pulse drives [1]. Therefore, a supply-inverted bipolar pulser and a Tx/Rx switch are proposed to drive CMUTs in medical ultrasound imaging applications. These circuits are particularly suitable for intracardiac echocardiography (ICE) catheters where interface electronics and transducer arrays are integrated at the tip and low supply voltages are desired for safety. The proposed pulser generates a bipolar signal with a peak-to-peak voltage that is almost twice the supply level, which improves the driving capability compared to conventional supply-limited pulser, enabling operation at lower supply voltage, and the switch is able to protect Rx electronics during the transmit phase.