Intrauterine growth restriction (IUGR) is an anomaly of fetal growth dynamics, which is mainly caused by alterations in the vascular remodeling of utero-placental arteries. With a prevalence of 10% of pregnancies, IUGR remains the leading cause of perinatal mortality. Doppler velocimetry is the common screening tool for IUGR but this imaging modality remains controversial. In this context, we evaluated contrast-enhanced ultrasound (CEUS) as a new modality to monitor the uteroplacental perfusion and to discriminate physiological pregnancy from IUGR in rat model.