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We have studied C-mode and B-mode imaging using high-frequency ultrasonic waves through a thin fiber for direct observation of the microscopic image of tissue. We reported previously that the C-mode images of the tissue on the glass and B-mode image of animal bone placed in water were obtained using a fused quartz fiber as the needle-type ultrasound probe. In this paper, we propose a method for the...
Acoustic droplet vaporization (ADV) has shown a great potential in extravascular tumor-targeting theranostics. The mechanical perturbations produced during ADV process (e.g. initial volume expansion, cavitation, and movement of the bubble) on the nearby cells could cause cell dysfunction with irreversible cell membrane damage or facilitate drug delivery due to sonoporation. A confocal acousto-optical...
Vector Doppler techniques are ready to substitute the standard Doppler methods currently employed in clinical blood velocity investigations. However, like in classic Pulse-Wave modes, the maximum detectable velocity is related to the Pulse Repetition Frequency (PRF), which is limited by the maximum depth and/or by hardware constraints. Unfortunately, the blood velocity, e.g. in stenotic vessels, can...
Focused ultrasound can effectively treat tumors by thermal ablation, but treatment times associated with mechanical or electronic scanning of single foci can be prohibitively long. Maximizing the energy efficiency of focused ultrasound ablation may decrease treatment time while also decreasing sensitivity to perfusion. One proposed approach [Mast et al., US Patent 9132287, 2015] creates multiple foci...
Fast cardiac imaging requires a reduction of the number of transmit events. This is typically achieved through multi-line-transmission (MLT) and/or multi-line-acquisition (MLA) techniques. However, restricting the field-of-view (FOV) to the anatomically relevant domain, e.g. the myocardium, can increase frame rate (FR) further. Using computer simulations, we previously proposed an anatomical scan...
For several use cases of complex processing algorithms on ultrasound NDT data, it is mandatory to ensure real-time signal processing speed. This can be achieved by using e.g. a field programmable gate array (FPGA). Sparse signal recovery (SSR) and compressed sensing (CS) methods are used for superior reconstruction of flaws from compressed measurement data. SSR and CS are currently a hot research...
Tissue Doppler Imaging (TDI) is an excellent tool for early detection of myocardial dysfunction, as well as for prognosis and follow-up of the myocardial function after surgical treatment. However, since it exploits the same principles of color flow imaging, TDI requires to balance frame rate with field of view. A novel TDI technique based on multiline transmission (MLT), i.e. the simultaneous transmission...
Tissue Doppler Imaging (TDI) is an excellent tool for early detection of myocardial dysfunction, as well as for prognosis and follow-up of myocardial function after surgical treatment. However, since it exploits the same principles of color flow imaging, TDI requires to balance frame rate with field of view. A novel TDI technique, based on multi-line transmission and multi-line acquisition, was shown...
Bulk thermal ablation, including radiofrequency ablation (RFA) as well as microwave and ultrasound (US) ablation, is an important approach to tumor treatment. To avoid incomplete treatments and cancer recurrence while reducing morbidity, a real-time monitoring and control approach, capable of providing consistent thermal ablation in minimum time, is needed. Echo decorrelation imaging has been successfully...
A novel ultrasound (US) platform with high channels density is a pre-requisite to open new frontiers in diagnostic and/or therapy by experimental implementation of new enabled advanced techniques. To date, few systems in the world permit to have a full and simultaneous control both in transmit and receive of all single elements of arrays with more than 1000 transducers. This paper presents a powerful...
We have designed and implemented an ultrasonic imaging research platform that performs all signal processing, including beamforming and image processing, using software on a GPU. An operating software is developed on a PC that can control RF data acquisition hardware to accommodate ultrasound images of various formats. Beamforming methods that include conventional scan line based imaging, scan line-based...
Achieving a high frame rate in echocardiography is highly important for quantifying the short phases of the cardiac cycle that contain valuable information for medical diagnosis. Additionally, the 3D quantitative assessment of the heart would significantly improve the current measurements used in daily clinical routine. Nevertheless, obtaining ultrafast images remains a challenge due to the trade-off...
In a few years, ultrasound research platforms, also known as open scanners, have become a great tool for facilitating the experimental activities of ultrasound labs. An ideal platform should be easily programmed to permit the transmission of arbitrary sequences of arbitrary waveforms, the acquisition of huge amounts of raw echo-data, the visualization of the region of interest and, possibly, the real-time...
A great need exists to non-invasively quantify the neurotransmitter activity in real-time to build a comprehensive functional map of a brain. In this paper, we present real-time recording of neuronal membrane potential change in vivo using transcranial photoacoustic (PA) voltage-sensitive dye (VSD) imaging on a rat in seizure.
Modern industries need to monitor every step of the production process for a better efficiency and product quality. However, important parameters, like the rheological indexes of the fluids involved in the process, cannot easily be inspected inline, as they are typically analyzed through off-line laboratory tests on specimens. Recently, electronics sensors have been introduced capable to characterize...
A dual beam vector Doppler method was proposed (DOI: 10.1016/j.ultrasmedbio.2009.11.004), in which one beam is continuously tracked perpendicular to the flow direction, and the second one is used to perform velocity measurements with known Doppler angle. Since two consecutive transmission (TX) and reception (RX) events (one for each beam) are needed, the effective Doppler pulse repetition frequency...
Pressure measurements within the chambers of the heart yield critical information for diagnosis and management of cardiac patients (∼92 million Americans), but cardiac catheterization procedure is invasive and expensive. Subharmonic aided pressure estimation (SHAPE) may be able to estimate intra-cardiac pressures noninvasively, if the optimum incident acoustic output (IAO) for SHAPE can be established...
Eigen-filters with attenuation response adapted to clutter statistics in color flow imaging (CFI) have shown improved flow detection sensitivity in the presence of tissue motion. However, its practical adoption for routine use in clinical scanners is hindered by the long processing time required to derive the eigen-components. In this work, we seek to overcome this issue by formulating a parallel-computing...
Vector Doppler techniques are ready to substituting the standard methods for blood velocity investigation. However, like in classic Pulse Wave methods, the maximum detectable velocity is related to the Pulse Repetition Frequency (PRF), which is limited by the maximum depth and/or hardware constraints. Unfortunately, the blood velocity, e.g. in stenotic vessels, can easily peak at 2m/s, thus resulting...
Most commercially available ultrasound imaging systems currently implement the delay and sum (DAS) beamforming. Alternative beamformers have been presented, offering higher performance at the expense of computational complexity, which has so far limited their actual implementation. In particular, the Filtered-Delay Multiply and Sum (F-DMAS) beamformer, which adds the computation of signed square roots,...
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