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Flow velocity estimation is an important feature in ultrasound imaging. However, in conventional color Doppler imaging, only parallel flow components can be estimated, the velocity information is not simultaneously measured throughout the region of interest (ROI) due to sequential firing of the ultrasound beams, and the size of the ROI is limited under frame rate concerns. On the other hand, ultrafast...
Flow cytometer plays a key role in cell sorting and analysis. For a higher detection precision, sheath flow is adopted to avoid the turbulent or vortex effect when the cell flowing through a capillary tube during the cell counting in many commercial cytometers. This method works well when the low flow velocity is relatively low. However, in order to have a higher analysis efficiency for clinical laboratories,...
Accurate diagnosis of non-alcoholic steatohepatitis (NASH) is a critical issue in current clinical practice. Non-invasive diagnosis of NASH can be achieved by quantitative ultrasound (QUS), which requires a detailed understanding tissue-specific acoustic microstructure at cellular scale (i.e., 10 μm). Therefore, QUS methods would benefit from the knowledge of the acoustic properties of organelles...
Ultrasound B-scan imaging systems operate under some well known resolution limits. To improve resolution, the concept of stable pulses, having bounded inverse filters, were described for lateral deconvolution (Chen and Parker, Enhanced resolution, J Med Imaging, 2016). This framework has been extended to the axial direction, enabling two-dimensional deconvolution.
Although 3D ultrasound plays an increasingly important role, 2D echocardiography remains the main clinical imaging modality for cardiac function assessment in daily practice. This requires precise delineation of the myocardium at end diastole (ED) and systole (ES). Because of intrinsic high variability in image quality, manual interactions are still needed. In this study, we investigate a machine...
Patients with a 70–99% stenosed carotid artery will undergo surgery to prevent rupture of the plaque. However, the degree of stenosis does not determine the vulnerability of the plaque, since vulnerability depends on the plaque's morphology, mechanical properties and the force acting on the plaque. Mechanical models of the carotid artery can improve decision-making of the surgeon by quantifying and...
We have developed a new, fast and simple 3D imaging approach referred to as Simultaneous Azimuth and Fresnel Elevation (SAFE) compounding. The principle behind this technique is to perform conventional plane wave compounding with the bottom set of electrodes, while implementing a reconfigurable Fresnel elevation lens with the top electrodes. While a Fresnel lens would usually result in unacceptable...
Noninvasive electrical brain imaging in humans often suffers from poor spatial resolution due to the uncertain spread of electric fields through the head. To overcome this limitation, we propose 4D transcranial acoustoelectric brain imaging (tABI) for mapping current densities at a spatial resolution confined to the ultrasound (US) focus. Acoustoelectric (AE) imaging exploits an interaction between...
In this paper, we present a front-end integrated circuit (IC) for an ultrasound neurostimulation system, to be interfaced with a 16×16 2D CMUT array to realize an ultrasound field pattern (USFP) using quantized phases and amplitudes. The IC uses a pulse width modulation (PWM) technique with a three-level pulse to generate excitation signals having multi-level quantized amplitudes. For a programmable...
Carotid plaque vulnerability is difficult to characterize from B-mode ultrasound imaging alone. However, elastographic characterization of plaque mechanical properties may aid in the assessment of vulnerability. As an initial step to understand the complex wave propagation that can occur in plaques, we have developed simulation models that incorporate different shear moduli (μ) of the arterial wall,...
Transcranial Doppler Ultrasound (TCD) is one of the techniques that have been used for stroke diagnosis. This paper compares the potential of three aperiodic sparse array configurations: random array; sunflower spiral array; and log spiral array for application to TCD. To cover the full temporal window, a 30mm diameter circular aperture is selected, with a 2MHz operating frequency to match current...
A noninvasive measurement of in situ acoustic intensity is useful in a variety of therapeutic applications such as ultrasound induced drug and gene delivery. Some previously proposed methods assumed other acoustic parameters such as scattering coefficient to be constant. This paper proposed a method free of such restrictions, by estimating all the relevant parameters using the highly nonlinear behaviors...
Fast acquisition sequences enable >200Hz 2D cardiac B-mode imaging with little compromise in image quality. Fast imaging minimizes frame to frame decorrelation, enabling radiofrequency (RF)-based tracking for enhanced signal-to-noise ratio (SNR) in motion and deformation imaging. Our objective was to compare the performance and clinical usefulness of Fast RF-based Tracking (FRFT) to the established...
Ultrasound is a widely used imaging modality, both for diagnosis and guidance of interventional procedures such as biopsies. Ultrasound imaging commonly provides 2D data, which can be a limitation for further data processing, since information like out-of-plane motion is inaccessible. In this study, a specific multi-row array transducer — developed for the elastography application — is presented....
3D Ultrasound systems present several technical challenges, particularly the large number of elements in a 2D array, high electrical impedance, and image acquisition time. Crossed electrode arrays address some of these issues, especially the huge reduction in number of elements. However, creating a two-way focused 3D image in real-time is difficult with these arrays because azimuth and elevation dimensions...
Tissue mechanical anisotropy has been shown to be diagnostically relevant in numerous clinical applications. Anisotropy can be assessed using acoustic radiation force-based techniques, including Acoustic Radiation Force Impulse (ARFI) and Viscoelastic Response (VisR) ultrasound. In this work, ARFI peak displacement (PD), as well as VisR relative elasticity (RE) and relative viscosity (RV), were implemented...
Cardiac pathologies are often characterized by important changes of myocardial properties such as the myocardial stiffness, re-organization of muscle fiber structure, modification of the microcirculation flow, all of which remain challenging to assess quantitatively and non-invasively in vivo. Over the last decade, the advent of software-based systems has enabled the implementation of ultrafast ultrasound...
A recent study showed that focused ultrasound can noninvasively create neural response in the retina in a similar way to light stimulus. To implement such functionality, we developed an algorithm for a 2D transducer array to project an image to the retina as an ultrasound field pattern (USFP) in a previous study. In this work, we report a front-end integrated circuit (IC) for a 2D CMUT array that...
The authors developed phase-sensitive and fast mechanical scanning laser probe system as a diagnosis tool for RF SAW/BAW devices[1]. Captured 2D image of wave field brings valuable information such as energy leakage and standing wave pattern with a help of a wavenumber domain analysis[2] for a specified driving frequency. Although the system is frequently used by external researchers and engineers...
Transarterial chemoembolization (TACE) is standard of care for patients with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma (HCC). Current guidelines recommend follow-up imaging 4–6 weeks after treatment. An earlier indicator of residual disease would enable clinicians to retreat sooner, potentially improving disease control. In this study, time-intensity curves from 3D contrast-enhanced...
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