The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Long term reliability has been a challenging issue in CMUT probe development. Kolo Medical Inc. has worked on improving reliability of CMUT probes for many years. Testing methods were developed and utilized to assess long term reliability and evaluate CMUT design improvements. A large amount of long term reliability test data were collected and analyzed.
The aim of this study is to investigate how the intracellular ROS responds to different degrees of sonoporation. Using a customized platform for 1.5-MHz ultrasound exposure (13.33-μs duration and 0.70-MPa peak negative pressure) and observing the dynamics of sonoporation and intracellular ROS at the single-cell level, we quantified the exogenous molecular uptake and intracellular ROS indicator to...
It was estimated that annual cost of measurable medical errors was higher than $17 billion in 2008. Phantoms are objects manufactured using a tissue mimicking material (TMM) and largely used to test protocols and mimic clinical environment for medical training. TMM should reproduce at least one biological property to allow the association with clinical situation. The gel made by the copolymer styrene-ethylene/butylene-styrene...
For drug-resistant epilepsy patients, epilepsy surgery is the only option. In clinic, this is done with subdural electrode array with a disappointing low spatial resolution of ∼ 1cm. In order to improve clinical cure rate, ultrasound imaging technique can be cooperated with Electrocorticography to monitor the maps of seizure. We propose to develop the implanted single ultrasound transducers 3mm×1...
An effective imaging modality to delineate ablated regions after microwave ablation (MWA) therapy is crucial to yield successful treatment outcomes. Ultrasound B-mode imaging is widely used to guide the ablation antenna placement. However, the image quality suffers from relatively low imaging contrast due to the similar echogenicity between the ablated and surrounding tissue. In this study, we applied...
As one of the most important and well established tools, ultrasound imaging provides noninvasive valuable diagnostic information, especially in the form of cross-sectional images of soft tissues. In this work, we report the design, fabrication, and characterization of press-focused LiNbO3 transducer with one matching layer only. The performance of these transducers is in good agreement with the simulation...
Photoacoustic imaging is a hybrid imaging modality where ultrasound signal is generated when laser pulses are absorbed by tissue. Tissue-mimicking phantom is a useful tool to characterizing new imaging methods. However, there is still a lack of development of phantoms applied to hybrid modalities such as photoacoustics. SEBS gel is a translucent material and present acoustic and elastic properties...
A novel ultrasound (US) platform with high channels density is a pre-requisite to open new frontiers in diagnostic and/or therapy by experimental implementation of new enabled advanced techniques. To date, few systems in the world permit to have a full and simultaneous control both in transmit and receive of all single elements of arrays with more than 1000 transducers. This paper presents a powerful...
Microbubble based contrast-enhanced ultrasound (CEUS) enables the visualization of vascularity given the tendency of microbubbles to function as a blood pooling agent. Using contrast specific ultrasound (US) imaging, it is possible to quantify the kinetics of these agents and derive various perfusion metrics. In this ongoing clinical study, we evaluate the feasibility of using these microbubble based...
Cervical spine pathoanatomy is typically evaluated by static radiographs, CT or MRI; however, these modalities are unable to directly measure the dynamic performance of the spine that account for its functionality. We have developed an ultrasound based technique that provides a non-invasive, realtime, quantitative, textitin-vivo image of the C-spine that allows for assessment of the dynamic motion...
Infrastructures such as bridges, railways and roads are vital to every country's economic growth and development. These are usually reinforced concrete structures which need regular monitoring for operation and safety. The large concrete structures pose many challenges for inspection due to surface roughness, inhomogeneities and size of aggregates. Nondestructive testing is one of the most effective...
Off-axis clutter is a significant cause of image degradation in ultrasound. We propose an adaptive approach for clutter reduction based on the principle that off-axis signals show as relatively high spatial frequencies in the per-channel data. For each pixel, an M∗N per-channel data matrix is extracte from the aligned data received from different observations of that pixel (N = number of channels,...
Acoustoelectric imaging (AEI) is a new technique for mapping current densities at high resolution depending on the size of the ultrasound (US) focus. The design and performance of the recording system is crucial for efficient AEI because the amplitude of the AE signal in biological tissue is on the order of a microvolt or less. In this direction, an AE signal processing circuit (AE-SPC), containing...
The last 20 years have seen the development of fetal surgery, particularly for the treatment of twin-to-twin transfusion syndrome (TTTS). Although fetoscopy increases survival rate, it is also invasive and responsible for fetal and maternal complications affecting the neonatal outcome. A completely non-invasive treatment that could occlude deep anastomoses would prevent the risks of invasive fetoscopy...
Ultrasound imaging is a real-time and high frame rate modality suitable for the analysis of tendon dynamics, e.g. for diagnosis of carpal tunnel syndrome. Tendon displacement quantification algorithms based on speckle tracking are sensitive to underestimation due to stationary clutter present in the tendon region. In this study we propose an improved speckle tracking method based on Singular Value...
Early detection of pathological processes is crucial for the prognosis and treatment of patients, which can be facilitated through studying tissue biomechanical properties. Shear wave elastography is a technique to estimate the shear modulus of tissue. Such measurements quantify elasticity linearized around an immediate state of local stress condition, under applied nature of excitation. Stress-strain...
A transparent transducer array is desired in backward-mode photoacoustic imaging (PAI). CMUT technology is especially suitable for this application because of its wide bandwidth and a wide selection of processing materials. We have previously demonstrated a single-element CMUT with an ITO bottom electrode for improved transparency. The device showed 40% to 70% optical transmission from 700 nm to 900...
Lagrangian carotid strain imaging (LCSI) involves estimation of deformation in the carotid artery due to blood pressure variations under cardiac pulsation. Local strain over a cardiac cycle is tracked, which is computationally intensive. We incur long offline processing times for LCSI which becomes a limiting factor for clinical adoption. We report on the computational speedup obtained for a parallelized...
Subharmonic aided pressure estimation (SHAPE) uses ultrasound contrast agents (UCAs) to estimate hydrostatic pressure by transmitting at one frequency, receiving at its subharmonic frequency and then monitoring the subharmonic amplitude variations. The subharmonic response of the UCAs has an inverse linear relationship with the ambient pressure. In order to optimize SHAPE, we studied the impact of...
Targeted ultrasound contrast agents, comprising shell stabilized gas filled microbubbles (MBs), can be used to detect molecular markers of disease present on the vascular endothelium. Current MB imaging techniques exploit the nonlinear echo response of microbubbles to provide signal contrast with respect to adjacent tissue signal. However, these methods are hampered by false positive artifacts arising...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.