The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
We investigated the morphological and electrochemical properties of an explanted laser-machined 32 channel electrocorticogram (ECoG) electrode array made of platinum-iridium and silicone rubber. It was connected to a wireless brain-computer interface (BCI) and implanted in a sheep for more than 15 months. Recordings and stimulations of cortical activity were conducted over the whole period on a regularly...
Pressure ulcers, commonly called bedsores, are defined as injuries to the skin and underlying tissue resulting from prolonged pressure usually on bony areas of the body, such as heels and hips. In order to alleviate pressure accumulation at high-risk regions, the current practice in clinics requires caregivers to reposition their patients every two hours. This relies on the engagement of nursing services...
This paper presents a power-efficient implantable optogenetic interface using a wireless switched-capacitor based stimulating (SCS) system. The SCS efficiently charges storage capacitors directly from an inductive link and periodically discharges them into an array of micro-LEDs, providing high instantaneous power without affecting wireless link and system supply voltage. A custom-designed computer...
Marine derived long chain polyunsaturated fatty acids (PUFAs) were found to have benefits in reducing inducibility and maintenance of atrial fibrillation (AF) in a dog model. This study was conducted to evaluate the effect of PUFAs on local atrial electrical conduction properties acquired via a multi-electrode plaque sutured to the posterior wall of the left atrium of the heart in these dogs. Eleven...
While mammography remains the gold standard for breast cancer screening, additional adjunctive tools for early detection of breast cancer are needed especially for young women, women with dense breast tissue and those at increased risk due to genetic factors. These patient populations, along with those populations for whom mammography is not readily available, require alternative technologies capable...
Advancements in neural interfaces capable of neural stimulation have shown that neural implants may potentially target the central nervous system to treat neurological disorders. Unfortunately, many of the current technologies used to stimulate and record from the brain do not suffice for this purpose; those that provide a sufficient channel density, which is required for interfacing and chronic functionality...
An element design for receive array coils that decouples from the transmit coil without external active detuning is presented for magnetic resonance imaging (MRI) of mice. The array element uses a crisscrossed geometry on the return paths to reduce the current induced by the transmit coil. Without the need for an external active detune network, the proposed method simplifies the construction of MRI...
In this paper, a miniaturized bioreactor for accelerating nerve growth is developed to investigate potentially bi-directional peripheral neural interface based on tissue engineering. The bioreactor consisting of two parallel chambers that are extended to conduct controlled trials for optimized neuronal culture. The chamber is used to improve the micro-environment of in vitro nerve regeneration in...
This paper presents a new approach for analyzing center of pressure (COP) progression using pressure data collected from a pressure-sensitive array placed under the bed mattress. Pressure data were collected from a young female participant who was healthy and an older 78 year old female participant who had a history of falls. Information relevant to movement direction, time, path trajectory, magnitude...
Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control and feel of robotic prosthetic limbs. We have developed a Regenerative Multi-electrode Interface (REMI) that guides re-growing axons through an electrode array deployed in the lumen of a nerve guide. While acute studies have shown the use of the REMI in the rat sciatic nerve, the quality of chronic...
Bioelectronic medicine is an emerging field that relies on electrical signals to modulate complex neuronal circuits, particularly in the peripheral nervous system, as an alternative to drug-enabled therapeutics. Small autonomic nerves are one of the targets in this field, however, interfacing peripheral nerves smaller than 300 Dm remains a challenge. Here we report the development of a Microchannel...
Microlens arrays have been widely used as an essential component in many optical systems. The conventional fabrication techniques, such as ink-jet printing, photoresist thermal reflow, grayscale photolithography, and LIGA process have some drawbacks in aspects of process complexity and high fabrication cost. This paper presents a low-temperature, rapid and cost-effective method to successfully generate...
This paper presents results from a pilot experiment in which the technique of velocity selective recording (VSR) was used to identify naturally occurring electroneurogram (ENG) signals within the intact nerve of a rat. Signals were acquired using a set of electrodes placed along the length of the nerve, formed from simple wire hooks. This basic form of recording has already been applied in-vivo to...
Ion channels play critical roles in transporting chemical species into and out of cells. Ion channels are also targets for drug discovery and new receptor-based analytical technologies. To better understand ion channel structure and function, a high throughput membrane protein characterization microsystem is being developed. This microsystem integrates a 1024-element array of planar bilayer lipid...
Non-invasive EEG recordings are subject to effects such as surface conduction, resulting in very low signal to noise ratio (SNR). The conventional approach of using signal averaging to improve the SNR cannot be used for single trial EEG estimation. As such, this paper proposes a beamforming based technique that can be used to improve the signal quality from a signal trial EEG measurement. Results...
Practical application of intracortical microelectrode technology is currently hindered by the inability to reliably record neuronal signals chronically. The precise mechanism of device failure is still under debate, but most likely includes some combination of tissue reaction, mechanical failure, and chronic material degradation. Impedance is a measure of the ease with which current flows through...
Clinical electrodes for epileptic seizure monitoring traditionally require a tradeoff between coverage area and spatial resolution. However, with multiplexed, flexible array devices, high spatial resolution is possible over large surface areas. This high resolution data, recorded from 360 electrodes or more, is difficult to review manually for subtle patterns. Here we develop innovative methods for...
We demonstrate a self-powered chip to detect motion which enables constant, non-invasive monitoring. The chip was implemented in a standard 0.18 μm CMOS process. A P-N junction photodiode array was fabricated in the chip to detect when light is blocked by the movement of a hand or finger. The interface circuit detects the change between the shadowing and the exposure to determine the specific movement...
Radar based microwave imaging (MI) has been widely studied for breast cancer detection in recent times. Sensing dielectric property differences of tissues over a wide frequency band has been made possible by ultra-wideband (UWB) techniques. In this paper, a flexible, compact monopole antenna on a 100 μm Kapton polyimide is designed, using a high frequency structure simulator (HFSS), to be in contact...
Surgical resection of epileptogenic foci is often a beneficial treatment for patients suffering debilitating seizures arising from intractable epilepsy [1], [2], [3]. Electrodes placed subdurally on the surface of the brain in the form of an ECoG array is one of the multiple methods for localizing epileptogenic zones for the purpose of defining the region for surgical resection. Currently, transcutaneous...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.